Reversine | Reverses differentiated cells to multipotent stem cells

Reversine (656820-32-5) induces differentiated myogenic-lineage-committed cells to become multipotent mesenchymal progenitor cells.^1-2 Acts as a selective human A₃ adenosine receptor antagonist (K_i = 0.66 μM).³ Cell permeable.

References/Citations
1) Chen et al. (2004), Dedifferentiation of lineage-committed cells by a small molecule; J. Am. Chem. Soc., 126 410
2) Chen et al. (2007), Reversine increases the plasticity of lineage-committed mammalian cells; Proc. Natl. Acad. Sci. USA, 104 10482
3) Perreira et al. (2005), Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists; J. Med. Chem., 48 4910