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RGFP966 | Selective HDAC3 inhibitor

RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited @ 15µM).1 It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5

References/Citations

1) Malvaez et al. (2013), HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA 110 2647
2) Bieszczad et al. (2015), Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci. 35 13124
3) Zhu et al. (2017), HDAC3 negatively regulates spatial memory in a mouse model of Alzheimers disease; Aging Cell 16 1073
4) Haiqun et al. (2016), The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498
5) Janczura et al. (2018), Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA 115 E11148

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Catalog#  10-4029-0005

$70.00
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CAS:
1357389-11-7
Catalog Number:
10-4029
Activity:
Selective HDAC3 inhibitor
Chemical Name:
(2E)-N-(2-Amino-4-fluorophenyl)-3-[(2E)-1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Molecular Weight:
362.40
Molecular Formula:
C21H19FN4O
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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