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Product Details

Ribociclib | CDK4/6 inhibitor

Ribociclib (1211441-98-3) is a clinically useful, potent, and specific CDK4/6 inhibitor.1,2,3  It was recently approved for use in HR+, HER2- metastatic breast cancer.

References/Citations

1) Rader et al. (2013), Dual CDK4/6 inhibition induces cell-cycle arrest and senescence in neuroblastoma; Clin. Cancer Res. 19 6173
2) Kim et al. (2013), LEE011: an orally bioavailable, selective small-molecule inhibitor of CDK4/6 – reactivating Rb in cancer; Mol. Cancer Ther. 12 PR02
3) Tripathy et al. (2017), Ribociclib(LEE011): mechanism of action and clinical impact of this selective cyclin-dependent kinase 4/6 inhibitor in various solid tumors; Clin. Cancer Res. March 28, 2017

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Ribociclib | CDK4/6 inhibitor | CAS 1211441-98-3

Catalog#  10-4807-0010

$70.00
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CAS:
1211441-98-3
Catalog Number:
10-4807
Activity:
CDK4/6 inhibitor
Chemical Name:
7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Alternate Names:
LEE011
Molecular Weight:
434.54
Molecular Formula:
C23H30N8O3
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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