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Rufinamide | Anticonvulsant / Improves cognition

Rufinamide (106308-44-5) is a clinically useful anticonvulsant medication.1 Its mechanism of action is believed to be inhibition of Nav1.1 and Nav1.6 activation.2  Rufinamide improved cognitive function and increased neurogenesis in gerbils via increases in IGF-1, IGF-1R, and p-CREB.3

References/Citations

1) Hakimian et al. (2007), Rufinamide: a new anti-epileptic medication; Expert Opin. Pharmacother. 8 1931
2) Gilchrist et al. (2014), Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents; ACS Chem. Biol. 9 1204
3) Chen et al. (2018), Rufinamide, an antiepileptic drug, improves cognition and increases neurogenesis in the aged gerbil hippocampal dentate gyrus via increasing expressions of IGF-1, IGF-1R and p-CREB; Chem. Biol. Interact. 286 71

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Catalog#  10-4275-0010

$25.00
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CAS:
106308-44-5
Catalog Number:
10-4275
Activity:
Anticonvulsant / Improves cognition
Chemical Name:
1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Molecular Weight:
238.19
Molecular Formula:
C10H8F2N4O2
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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