SB-3CT | MMP2 inhibitor

CAS:
 292605-14-2
Catalog Number:
 10-2493

Available Options

Size:PriceQuantity 
5 mg$80.00
25 mg$290.00
Request Quote / Bulk / Custom Size
Product Inquiry

SB-3CT (292605-14-2) is a potent and selective inhibitor of MMP2 (Ki=28 nm) which also inhibits MMP9 (Ki=400 nM).1 The drug rescues laminin from proteolysis and neurons from apoptosis in a transient focal cerebral ischemia mouse model.2 It abrogates elevation of blood brain barrier (BBB) permeability in mouse Parkinson’s disease models3 and improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease4. BBB permeable.

References/Citations:

  1. Kleifeld et al. (2001), X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme; J. Biol. Chem., 276 17125
  2. Gu et al. (2005), A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia; J. Neurosci., 25 6401
  3. Ruan et al. (2022), Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model; Int. J. Mol. Sci., 23 2793
  4. Ringland et al. (2021), MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease; BMC Neurosci., 22 39
292605-14-2, MMP2 inhibitor, SB-3CT, SB-3CT supplier, SB3CT
CAS:
292605-14-2
Catalog Number:
10-2493
Activity:
MMP2 inhibitor
Chemical Names:
2-[[(4-Phenoxyphenyl)sulfonyl]methyl]-thiirane
Molecular Weight:
306.39
Molecular Formula:

C15H14O3S2

Solubility:
Soluble in DMSO (35 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

SB-3CT (292605-14-2) is a potent and selective inhibitor of MMP2 (Ki=28 nm) which also inhibits MMP9 (Ki=400 nM).1 The drug rescues laminin from proteolysis and neurons from apoptosis in a transient focal cerebral ischemia mouse model.2 It abrogates elevation of blood brain barrier (BBB) permeability in mouse Parkinson’s disease models3 and improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease4. BBB permeable.

References/Citations:

  1. Kleifeld et al. (2001), X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme; J. Biol. Chem., 276 17125
  2. Gu et al. (2005), A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia; J. Neurosci., 25 6401
  3. Ruan et al. (2022), Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model; Int. J. Mol. Sci., 23 2793
  4. Ringland et al. (2021), MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease; BMC Neurosci., 22 39

STEM CELL

BOGO