Sibiriline | Dual necroptosis and ferroptosis inhibitor

CAS:
 1346526-26-8
Catalog Number:
 10-3992
Sibiriline chemical structure

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Sibiriline (1346526-26-8) is a novel dual inhibitor of necroptosis and ferroptosis.1,2 It prevents necroptosis via inhibition of RIPK1 (IC50 = 1.1 µM) and ferroptosis via inhibition of phospholipid peroxidation acting as a radical trapping antioxidant. Sibiriline displayed neuroprotective effects in a mouse model of Parkinson’s disease.

 References/Citations:

  1. Le Cann et al. (2017), Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis; FEBS J. 284 3050
  2. Delehouze et al. (2025), Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phosphor)lipid peroxidation as a potential therapeutic strategy; Cell Death Discov. 11 552
1346526-26-8, Dual necroptosis and ferroptosis inhibitor, sibiriline, Sibiriline supplier
CAS:
1346526-26-8
Catalog Number:
10-3992
Activity:
Dual necroptosis/ferroptosis inhibitor
Chemical Names:
4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
Molecular Weight:
210.24
Molecular Formula:

C13H10N2O

Solubility:
Soluble in DMSO (at least 60 mg/ml)
Physical Properties:
Brown solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Sibiriline (1346526-26-8) is a novel dual inhibitor of necroptosis and ferroptosis.1,2 It prevents necroptosis via inhibition of RIPK1 (IC50 = 1.1 µM) and ferroptosis via inhibition of phospholipid peroxidation acting as a radical trapping antioxidant. Sibiriline displayed neuroprotective effects in a mouse model of Parkinson’s disease.

 References/Citations:

  1. Le Cann et al. (2017), Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis; FEBS J. 284 3050
  2. Delehouze et al. (2025), Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phosphor)lipid peroxidation as a potential therapeutic strategy; Cell Death Discov. 11 552

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