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Product Details

SIC5-6 | Separase inhibitor

Separase is a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers. SIC5-6 is an inhibitor of separase with no inhibition of the related protease caspase-1 in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment with 30 µM SIC5-6 indicating a potential attractive new chemotherapeutic target.

References/Citations
1) Henschke et al. (2019), Identification of Bioactive Small Molecule Inhibitors of Separase; ACS Chem. Biol. 14 2155

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Catalog#  10-4075-0010

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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Catalog Number:
10-4075
Activity:
Separase inhibitor
Chemical Name:
3,3’-(1-((4-Iodophenyl)sulfonyl)piperidine-4,4’diyl)bis(1H-indole)
Molecular Weight:
581.47
Molecular Formula:
C27H24IN3O2S
Solubility:
Soluble in DMSO (up to at least 50 mg/ml).
Physical Properties:
White solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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