SMER28 (CAS 307538-42-7) Induces autophagy via an mTOR-independent pathway. Enhances clearance of b-amyloid protein in cell lines and primary neuronal culture models.1-3 May be a useful lead compound for the development of new therapeutics for neurodegenerative diseases.4 Induces the release of articular cartilage vesicles from healthy articular chondrocytes in a dose- and time-dependent manner.5 Promotes reprogramming of fibroblasts to neural stem-like cells.6 Cell permeable.
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2) Tian et al. (2014), the convergence of endosomal and autophagosomal pathways; implications for APP-CTF degradation; Autophagy, 10 694
3) Shen et al. (2011), Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies; Cell Biochem. Biophys., 60 173
4) Renna et al. (2010), chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases; J. Biol. Chem., 285 11061
5) Rosenthal et al. (2015), Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes; J. Biol. Chem., 290 13028
6) Zhang et al. (2016), Phamracological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation; Cell Stem Cell., 18 653