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SMER-28 | Autophagy inducer

SMER28 (CAS 307538-42-7) Induces autophagy via an mTOR-independent pathway. Enhances clearance of b-amyloid protein in cell lines and primary neuronal culture models.1-3  May be a useful lead compound for the development of new therapeutics for neurodegenerative diseases.4 Induces the release of articular cartilage vesicles from healthy articular chondrocytes in a dose- and time-dependent manner.5  Promotes reprogramming of fibroblasts to neural stem-like cells.6 Cell permeable.

References/Citations

1) Tian et al. (2011), A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway; FASEB J., 25 1934
2) Tian et al. (2014), the convergence of endosomal and autophagosomal pathways; implications for APP-CTF degradation; Autophagy, 10 694
3) Shen et al. (2011), Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies; Cell Biochem. Biophys., 60 173
4) Renna et al. (2010), chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases; J. Biol. Chem., 285 11061
5) Rosenthal et al. (2015), Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes; J. Biol. Chem., 290 13028
6) Zhang et al. (2016), Phamracological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation; Cell Stem Cell., 18 653

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Focus Biomolecules cell signaling reagent supplier, chemical structure of SMER28 | Autophagy inducer | CAS 307538-42-7

Catalog#  10-1287-0005

$38.00
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CAS:
307538-42-7
Catalog Number:
10-1287
Activity:
Autophagy inducer
Chemical Name:
6-Bromo-4-allylaminoquinazoline
Molecular Weight:
264.12
Molecular Formula:
C11H10BrN3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 2 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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