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Product Details

TAME | Ubiquitin ligase inhibitor

TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2

References/Citations
1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382
2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383

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TAME | 1784-03-8 | Structure | Supplier

Catalog#  10-1364

$45.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1784-03-8
Catalog Number:
10-1364
Activity:
Ubiquitin ligase inhibitor
Chemical Name:
N-p-Tosyl-L-arginine methyl ester hydrochloride
Molecular Weight:
378.87
Molecular Formula:
C14H22N4O4S HCl
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Water (up to 30 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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