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Product Details

Tolcapone | COMT inhibitor / TTR aggregation inhibitor

Tolcapone (134308-13-7) is a catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity.2 Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo.3 Inhibits O-methylation of exogenous polyphenols such as EGCG.4 Cell permeable. Orally bioavailable.


1) Manisto et al. (1992), Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat; Br, J. Pharmacol., 105 569
2) Giovanni et al. (2010), Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity; J. Biol. Chem., 285 14941
3) Sant’Anna et al. (2016), Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity; Nat. Commun., 7 10787
4) Forester and Lambert (2015), The catechol-O-methyltranseferase inhibitor, tolcapone, increases the bioavailability of unmethylated (-)-epigallocatechin-3-gallate in mice; Funct. Foods, 17 183

Focus Biomolecules supplier, chemical structure of Tolcapone | COMT inhibitor | TTR aggregation inhibitor | CAS 134308-13-7

Catalog#  10-3075-0010

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Catalog Number:
COMT inhibitor / TTR aggregation inhibitor
Chemical Name:
Alternate Names:
Ro 40-7592
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Yellow solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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