TRIM-473 | RING ligase TRIM58 ligand

CAS:
 N/A
Catalog Number:
 10-4042

Available Options

Size:PriceQuantity 
5 mg$85.00
25 mg$295.00

TRIM-473 is a ligand (EC50 = 5.3 µM) for the PRY-SPRY domain of the RING ligase TRIM58.  An interesting new tool for the development of heterobifunctional degraders of this novel tissue-selective (erythroid precursor cells) ligase.

References/Citations:

  1. Hoegenauer et al. (2023), Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase; ACS Med. Chem. Lett., 14 1631
CAS:
N/A
Catalog Number:
10-4042
Activity:
RING ligase TRIM58 ligand
Chemical Names:
N2-(3-(Dimethylamino)propyl)-6-phenyl-N4-(piperidin-4-ylmethyl)quinazoline-2,4-diamine
Molecular Weight:
418.59
Molecular Formula:

C25H34N6

Solubility:
Soluble in DMSO (at least 50 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee