Journal Club: An excellent review of the TRPV1 channel was recently published in Cell Calcium, covering its structure, activation, and modulation, as well as its role in neuro-immune interactions and pain.
One of the most interesting natural TRPV1 activators is resiniferatoxin, which is 500-1000 fold more potent than capsaicin, the active compound found in chili peppers.
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