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Product Details

Tunicamycin | ER stress inducer

Tunicamycin (11089-65-9) is a fermentation product from Streptomyces lysosuperificus.  Provided as a mixture of tunicamycin A (C14), B (C15), C (C16) and D (C17) homologs varying in the number of carbon atoms in the fatty acid chain.   The structure shown is for tunicamycin B (the C15 homolog).  Tunicamycin is a potent inhibitor of GlcNAc phosphotransferase which thereby inhibits glycoprotein biosynthesis.1 Causes endoplasmic reticulum stress-induced autophagy2 and unfolded protein response3. Tunicamycin arrests cell cycle in late G1.4

References/Citations

1) Langan et al. (1991), Isoprenoids and astroglial cell cycling: diminished mevalonate availability and inhibition of dolichol-linked glycoprotein synthesis arrest cycling through distinct mechanisms;  J. Cell Physiol., 149 284
2) Ding et al. (2007), Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival;  J. Biol. Chem., 282 4702
3) Jiang et al. (2007), Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response; Cancer Res., 67 5880
4) Ishii et al. (1987), Dolichol-linked glycoprotein synthesis in G1 is necessary for DNA synthesis in synchronized primary cultures of cerebral glia;  J. Neurochem., 49 1606

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Catalog#  10-2111

$74.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
11089-65-9
Catalog Number:
10-2111
Activity:
ER stress inducer
Molecular Weight:
840.0 (Avg)
Molecular Formula:
C38H62N4O16 (tun. B)
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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