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Product Details

U-18666A | Cholesterol transport inhibitor

U-18666A (3039-71-2) is an oxidosqualene reductase inhibitor.1 Inhibits the egress of cholesterol from late endosomes and lysosomes.2 U-18666A is also used to study Niemann-Pick disease and for assessing the importance of molecular trafficking through the lysosomal pathway in other conditions.3

1) Sexton et al. (1983) Effects of 3.beta.-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures; Biochemistry 22 5687
2) Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-_-[2-(diethylamino)ethoxy]androst-5-en-17-one; J. Biol. Chem. 264 11796
3) Cenedella, (2009) Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes; Lipids 44 477

Focus Biomolecules cell signaling reagent supplier, structure U-18666A | Cholesterol transport inhibitor | CAS 3039-71-2

Catalog#  10-1075

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Catalog Number:
Cholesterol transport inhibitor
Chemical Name:
3b-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
Molecular Weight:
Molecular Formula:
C25H41NO2 HCl
Soluble in DMSO (up to 30 mg/ml) or in Water (up to 30 mg/ml).
Physical Properties:
White or off-white solid
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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