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Valsartan | Angiotensin antagonist

Valsartan (137862-53-4) is a high affinity angiotensin AT1 receptor antagonist (Ki = 2.38 nM). Highly selective (30,000-fold) over AT2 receptors1,2. Normalizes the increased production of inflammatory cytokines in adipose and liver tissue in LPS-infused mice3. Valsartan is a clinically useful antihypertensive agent. Orally active.

References/Citations
1) Criscione et al. (1993), Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype; Br. J. Pharmacol., 110 761
2) Wexler et al. (1996), Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy; J. Med. Chem., 39 625
3) Iwashita et al. (2013), Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice; Adipocyte, 2 28

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Focus Biomolecules supplier, chemical structure of Valsartan | Angiotensin antagonist | CAS 137862-53-4

Catalog#  10-2052

$50.00
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CAS:
137862-53-4
Catalog Number:
10-2052
Activity:
Angiotensin antagonist
Alternate Names:
CGP-48933
Chemical Name:
(S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-pentanamido]butanoic acid
Molecular Weight:
435.52
Molecular Formula:
C24H29N5O3
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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