Vardenafil HCl | PDE5/6 inhibitor

CAS:
 224785-91-5
Catalog Number:
 10-1152
Vardenafil chemical structure

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Vardenafil HCl (224785-91-5) is a potent and selective inhibitor of phosphodiesterase 5 (PDE5), IC50=0.2 – 1.2 nM and PDE6, IC50=2 nM.1,2 Agents that raise intracellular cGMP levels represent potential therapeutics for cognitive disorders.3 Clinically useful agent for male erectile dysfunction.

References/Citations:

  1. Card et al. (2004) Structural basis for the activity of drugs that inhibit phosphodiesterases; Structure 12 2233
  2. Boyle et al. (2005) Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED; Bioorg. Med. Chem. Lett. 15 2365
  3. Kafi et al. (2026) The PDE5 inhibitor vardenafil enhances glutamatergic transmission through amyloid-beta and cellular prion protein; Neurotherapeutics 23 e00941
224785-91-5, BAY 38-9456, PDE5 inhibitor, PDE5/6 inhibitor, PDE6 inhibitor, Vardenafil, Vardenafil HCl supplier
CAS:
224785-91-5
Catalog Number:
10-1152
Activity:
PDE5/6 inhibitor
Chemical Names:
2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one, hydrochloride
Alternate Name:
BAY 38-9456
Molecular Weight:
525.07
Molecular Formula:

C23H32N6O4S·HCl

Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Vardenafil HCl (224785-91-5) is a potent and selective inhibitor of phosphodiesterase 5 (PDE5), IC50=0.2 – 1.2 nM and PDE6, IC50=2 nM.1,2 Agents that raise intracellular cGMP levels represent potential therapeutics for cognitive disorders.3 Clinically useful agent for male erectile dysfunction.

References/Citations:

  1. Card et al. (2004) Structural basis for the activity of drugs that inhibit phosphodiesterases; Structure 12 2233
  2. Boyle et al. (2005) Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED; Bioorg. Med. Chem. Lett. 15 2365
  3. Kafi et al. (2026) The PDE5 inhibitor vardenafil enhances glutamatergic transmission through amyloid-beta and cellular prion protein; Neurotherapeutics 23 e00941

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