Veliparib 2HCl | PARP 1/2 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $140.00 |
Veliparib (912445-05-7) is a potent and selective PARP-inhibitor with Ki values of 5.2 nM and 2.9 nM for PARP-1 and PARP-2, respectively.1 Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells.4
References/Citations:
- Donawho et al. (2007), ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models; Clin. Cancer Res., 13 2728
- Yuan et al. (2018), ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts; PLoS One, 13 e0202860
- Wang et al. (2022), Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma; J. Clin. Lab Anal., 36 e24435
- Paterniti et al. (2021), Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, improved Cisplatin Effect in Human Oral Cell Carcinoma; Biomedicines, 9 771
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Veliparib (912445-05-7) is a potent and selective PARP-inhibitor with Ki values of 5.2 nM and 2.9 nM for PARP-1 and PARP-2, respectively.1 Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells.4
References/Citations:
- Donawho et al. (2007), ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models; Clin. Cancer Res., 13 2728
- Yuan et al. (2018), ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts; PLoS One, 13 e0202860
- Wang et al. (2022), Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma; J. Clin. Lab Anal., 36 e24435
- Paterniti et al. (2021), Poly (ADP-Ribose) Polymerase Inhibitor, ABT888, improved Cisplatin Effect in Human Oral Cell Carcinoma; Biomedicines, 9 771
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