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Veratramine | Cyclopamine analog

Veratramine (60-70-8) is a teratogenic steroidal alkaloid found in the corn lily (Veratrum sp.).1,2 It is an analog of cyclopamine which can inhibit the hedgehog signaling pathway-dependent proliferation in NIH/3T3 cells at 8 μM.1  Cell permeable.

SPECIAL HANDLING PRECAUTIONS: This product is teratogenic. Women who are, or may be pregnant should not handle veratramine

References/Citations

1) Tang et al. (2010), Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum;  Phytother. Res., 24 821
2) Mahindroo et al. (2009), Hedgehog-Gli signaling pathway inhibitors as anticancer agents;  J. Med. Chem., 52 3829

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Veratramine | 60-70-8 | Structure | Supplier

Catalog#  10-1147-0005

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
60-70-8
Catalog Number:
10-1147
Activity:
Cyclopamine analog
Chemical Name:
(3β, 23β)-14,15,16,17-Tetrahydroveratraman-3,23-diol
Alternate Names:
NSC 17821; NSC 23880
Molecular Weight:
409.60
Molecular Formula:
C27H39NO2
Solubility:
Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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