Cytoskeleton

The cytoskeleton is the structure that maintains a cell’s shape, internal organization, and provides support for essential cellular functions such as movement and division. It spans the cytoplasm and connects the cell nucleus with the extracellular matrix. Three main types of filamentous proteins comprise the cytoskeleton in eukaryotes: Microtubules (tubulin polymer) are the largest filament and are involved in maintaining the structure of the cell, cell division, providing a platform for intracellular transport, and moving various organelles and vesicles. Actin filaments are the smallest and are involved in specialized cell shapes, cytokinesis, and cell movement. There are several types of intermediate filaments (i.e. desmin, lamin, vimentin) but all are strong and involved in mechanical support of cellular structures. Pathologies related to cytoskeletal protein dysfunction include cancer, neurodegeneration, cardiovascular disease, pulmonary fibrosis and cirrhosis.

Actin

  • Phalloidin | Actin-binding agent
    CAS:
    17466-45-4
    Catalog Number:
    10-2359
  • MreB Inhibitor A22 | Disrupts bacterial actin cytoskeleton
    CAS:
    22816-60-0
    Catalog Number:
    10-5275
  • Cytochalasin B | Actin filament disrupting agent
    CAS:
    14930-96-2
    Catalog Number:
    10-2069
    Activity:
    Actin filament disrupting agent
    Fermentation product:
    from Drechslera dematioidea
    Alternate Name:
    NSC107658; Phominone
    Molecular Weight:
    479.61
    Molecular Formula:
    C29H37NO5
    Solubility:
    Soluble in DMSO (up to 5 mg/ml); Ethanol (10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Latrunculin A | Inhibits actin polymerization and microfilament organization
    CAS:
    76343-93-6
    Catalog Number:
    10-2254
    Activity:
    Inhibits actin polymerization and microfilament organization
    Molecular Weight:
    421.55
    Molecular Formula:
    C22H31NO5S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Mycalolide B | Actin depolymerizing agent
    CAS:
    122752-21-0
    Catalog Number:
    10-2217
    Activity:
    Actin depolymerizing agent
    Source:
    From Mycale sp.
    Molecular Weight:
    1027.16
    Molecular Formula:
    C52H74N4O17
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Actin Products

Kinesin

  • BTB-1 | Mitotic kinesin Kif18A inhibitor
    CAS:
    86030-08-2
    Catalog Number:
    10-1543
    Activity:
    Mitotic kinesin Kif18A inhibitor
    Chemical Names:
    4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; NSC 156750
    Molecular Weight:
    297.71
    Molecular Formula:
    C12H8ClNO4S
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Monastrol | Kinesin Eg5 and mitosis inhibitor
    CAS:
    254753-54-3
    Catalog Number:
    10-2629
    Activity:
    Kinesin Eg5 and mitosis inhibitor
    Chemical Name:
    1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
    Molecular Weight:
    292.35
    Molecular Formula:
    C14H16N2O3S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • K858 | Kinesin Eg5 inhibitor
    CAS:
    72926-24-0
    Catalog Number:
    10-1312
    Activity:
    Kinesin Eg5 inhibitor
    Chemical Name:
    N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
    Molecular Weight:
    277.35
    Molecular Formula:
    C13H15N3O2S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • S-Trityl-cysteine | Kinesin Eg5 inhibitor
    CAS:
    2799-07-7
    Catalog Number:
    10-1042
    Activity:
    Kinesin Eg5 inhibitor
    Chemical Name:
    (+)-S-Trityl-L-cysteine
    Molecular Weight:
    363.47
    Molecular Formula:
    C22H21NO2S
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
    Shipping Code:
    RT
View All Kinesin Products

Microtubules

View All Microtubules Products

Myosin

View All Myosin Products

Septins

  • UR214-9 | Septin inhibitor
    CAS:
    2456263-31-1
    Catalog Number:
    10-4397
  • Forchlorfenuron | Inhibits septin dynamics
    CAS:
    68157-60-8
    Catalog Number:
    10-3090
    Activity:
    Inhibits septin dynamics
    Chemical Name:
    1-(2-Chloro-4-pyridyl)-3-phenylurea
    Alternate Names:
    FCF, KT-30, CPPU
    Molecular Weight:
    247.68
    Molecular Formula:
    C12H10ClN3O
    Solubility:
    Soluble in DMSO or Ethanol
    Physical Properties:
    White or off-white solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date ofpurchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Septins Products