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Product Details

7-Aminoactinomycin D | Fluorescent DNA Probe

7-Aminoactinomycin D (7240-37-1) is a fluorescent, intercalating DNA-binding agent useful for identifying apoptotic cells by flow cytometry. 1,2 Capable of identifying populations representing live, apoptotic, and late apoptotic/dead cells in a quick, simple, reproducible, cost-effective fashion.3,4 Inhibitor of DNA-primed RNA polymerase and DNA polymerase.5

References/Citations

1) Telieps et al. (2013) Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection, Eur. J. Immunol. 43 1499
2) Schmid et al. (2007) Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D, Nat. Protoc. 2 187
3) Toba et al. (2000) Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY, Eur.J.Haematol. 64 10
4) Lecoeur et al. (1997) Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods, J. Immunol. Methods 209 111
5) Su et al. (1996) Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect, J. Immunol. 156 4198

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Catalog#  10-2053-0001

$74.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
7240-37-1
Catalog Number:
10-2053
Activity:
Fluorescent DNA probe
Molecular Weight:
1270.42
Molecular Formula:
C62H87N13O16
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Purple solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions should be made fresh daily.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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