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Programmed Cell Death

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 10058-F4 | Myc inhibitor | CAS 403811-55-2
    $50.00
    10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function1. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 17-DMAG | HSP90 inhibitor | CAS 150270-08-9
    $50.00
    17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell...

  • Focus Biomolecules supplier, chemical structure of 5-Fluorouridine | Proapoptotic antiproliferative agent | CAS 316-46-1
    $70.00
    5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1  Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms...

  • Focus Biomolecules cell signaling reagent supplier, structure Adapalene | Retinoid RARŒ≤, RARŒ≥ agonist | CAS 106685-40-9
    $30.00
    Adapalene (106685-40-9) is a stable analog of retinoic acid that acts as a selective agonist for RARβ and RARγ. Adapalene also inhibits proliferation and induces apoptosis in colorectal cancer cells in culture...

  • Focus Biomolecules cell signaling reagent supplier, structure of AG-1296 | PDGFR kinase inhibitor | CAS 146535-11-7
    $60.00
    AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells. References/Citations1) Kovalenko et al. (1997),...

  • Focus Biomolecules supplier, chemical structure of Ansamitocin P3 | Microtubule depolymerizer | CAS 66547-09-9
    $50.00
    Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin.1,2 Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity...

  • Focus Biomolecules supplier, chemical structure of Aphidicolin | DNA polymerase inhibitor | CAS 38966-21-1
    $70.00
    Aphidicolin (38966-21-1) specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apoptolidin | Apoptosis inducer | CAS 194874-06-1
    $248.00
    Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1 Is believed to act via inhibition of F0F1-ATPase2 but correlation studies indicate that a second mechanism may be the actual...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AT-101 | Bcl-2 inhibitor | CAS 90141-22-3
    $116.00
    AT-101 (90141-22-3) is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple...

  • Focus Biomolecules cell signaling supplier, chemical structure Beauvericin | Disrupts mitochondrial volume | CAS 26048-05-5
    $24.00
    Beauvericin (CAS 26048-05-5) induces apoptosis in A549 cancer cells.1 Disrupts mitochondrial volume regulation.2 Antifungal activity acting via inhibition of both multidrug efflux and TORC1 kinase.3 Crosses the blood-brain...

  • Focus Biomolecules supplier, chemical structure of Bexarotene | Retinoid RXR agonist | CAS 153559-49-0
    $40.00
    Bexarotene (153559-49-0) is a highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively).1 Clinically useful antineoplastic agent for cutaneous T-cell...

  • BI-D1870 | p90 ribosomal S6 kinase inhibitor
    $90.00
    BI-D1870 (501437-28-1) is an inhibitor of p90 ribosomal S6 kinase (RSK; IC50’s = RSK1, 31 nM; RSK2, 24 nM; RSK3, 18 nM; RSK4, 15 nM) with selectivity over other AGC kinases.1 It protected mice from experimental...

  • Focus Biomolecules supplier, chemical structure of Borrelidin | Angiogenesis inhibitor | CAS 7184-60-3
    $190.00
    Novel macrolide which inhibits bacterial and eukaryotic threonyl-tRNA synthetase.1 Displays potent anti-angiogenic activity (IC50=0.8 nM) and induces the collapse of newly formed capillary tubules.2 Modulates alternative...

  • Focus Biomolecules supplier, chemical structure of Bortezomib | Proteasome inhibitor | CAS 179324-69-7
    $50.00
    Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM).  Inhibits TNFα synthesis and FGF-induced angiogenesis. Clinically useful agent for...

  • Focus Biomolecules cell signaling reagent supplier, Brefeldin A | Inhibits intracellular transport | CAS 20350-15-6
    $30.00
    Brefeldin A (20350-15-6) is a specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Brefeldin A activates sphingomyelin metabolism. Cell permeable. References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BRL-50481 | PDE7 inhibitor | CAS 433695-36-4
    $60.00
    BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1 Induces apoptosis in chronic lymphocytic leukemia cells which express PDE7B.2 BRL-50481 increases...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of C-646 | HAT inhibitor | CAS 328968-36-1
    $80.00
    C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. C-646 enhances fear extinction memory and synaptic plasticity in...

  • Focus Biomolecules cell signaling reagent supplier, structure of Camptothecin | Topoisomerase I inhibitor | CAS 7689-03-4
    $30.00
    Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex...

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