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  • Focus Biomolecules reagent supplier, chemical structure of (+/-) RK-682 | Tyrosine phosphatase inhibitor | CAS 150627-37-5
    (+/-) RK-682 | Tyrosine phopshatase inhibitor
    $75.00
    RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7mu;M for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 10058-F4 | Myc inhibitor | CAS 403811-55-2
    10058-F4 | Myc inhibitor
    $50.00
    10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function1. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase...

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  • Abemaciclib | Potent and selective CDK 4/6 inhibitor
    Abemaciclib | Potent and selective CDK 4/6 inhibitor
    $50.00
    Abemaciclib (1231930-82-7) is a potent and selective CDK4/6 inhibitor (IC50 = 2 nM and 10 nM respectively).1 It caused G1 cell cycle arrest in colo-205 colorectal cells, MDA-MB-361 breast cancer cells, and MV4-11 AML cells...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Alisertib | Aurora A inhibitor | CAS 1028486-01-2
    Alisertib | Potent and selective inhibitor of Aurora A / Destabilizes Myc
    $60.00
    Alisertib (MLN8237, 1028486-01-2) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ALLN | Calpain inhibitor | CAS 110044-82-1
    ALLN | Calpain inhibitor
    $50.00
    ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1 Inhibits cell cycle progression at G1/S and...

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  • Focus Biomolecules supplier, chemical structure of Alsterpaullone | GSK3b inhibitor and CDK5/p25 inhibitor | CAS 237430-03-4
    Alsterpaullone | GSK3b inhibitor and CDK5/p25 inhibitor
    $56.00
    Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Alsterpaullone induces apoptosis2 and inhibits angiogenesis3...

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  • Focus Biomolecules supplier, chemical structure of Aphidicolin | DNA polymerase inhibitor | CAS 38966-21-1
    Aphidicolin | DNA polymerase inhibitor
    $70.00
    Aphidicolin (38966-21-1) specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    Apicidin | HDAC inhibitor
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    Apigenin | Protein kinase inhibitor
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

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  • AZ3146 | Mps1 kinase inhibitor
    AZ3146 | Mps1 kinase inhibitor
    $60.00
    AZ3146 (1124329-14-1) is a potent (IC50 = 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1 Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase...

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  • AZD1152-HQPA | Aurora B kinase inhibitor
    AZD1152-HQPA | Aurora B kinase inhibitor
    $50.00
    AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1 Aurora B Ki = 0.36 nM; Aurora A Ki = 1,369 nM.2 It inhibits the growth of tumors in multiple cancer models.3-6 Excessive ROS generation7 and...

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  • AZD7762 | Checkpoint kinase 1/2 inhibitor
    AZD7762 | Checkpoint kinase 1/2 inhibitor
    $60.00
    AZD7762 (860352-01-8, free base) is a potent and selective inhibitor of checkpoint kinases 1 and 2 (IC50 = 5 nM for both).1 It abrogates DNA damage-induced S and G2 checkpoints and enhances the efficacy of DNA damaging...

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  • Focus Biomolecules reagent supplier, chemical structure of Baicalein | Protein tyrosine kinase inhibitor | CAS 491-67-8
    Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    $40.00
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-277 | CHK2 inhibitor | CAS 516480-79-8
    BML-277 | CHK2 inhibitor
    $90.00
    BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CFM-4 | CARP-1 mimetic | CAS 331458-02-7
    CFM-4 | CARP-1 mimetic
    $70.00
    CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM)1. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CI-994 | HDAC Inhibitor | CAS 112522-64-2
    CI-994 | HDAC Inhibitor
    $30.00
    CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure of Colchicine | Microtubule depolymerizer | CAS 64-86-8
    Colchicine | Microtubule depolymerizer
    $40.00
    Colchicine (64-86-8) is a naturally occurring alkaloid which acts as an antimitotic agent by binding to tubulin and depolymerizing microtubules. Colchicine induces apoptosis in a variety of cell lines. References/Citations1)...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Crizotinib | c-MET and ALK inhibitor | CAS 877399-52-5
    Crizotinib | c-MET and ALK inhibitor
    $80.00
    Crizotinib (877399-52-5) is a potent and selective inhibitor of c-MET and ALK, IC50's=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of...

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  • Focus Biomolecules supplier, chemical structure of Dasatinib | Src and Bcr/Abl inhibitor | CAS 302962-49-8
    Dasatinib | Src and Bcr/Abl inhibitor
    $50.00
    Dasatinib (302962-49-8) inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively).1,2 Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell...

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  • Divin | Divisome assembly inhibitor
    Divin | Divisome assembly inhibitor
    $75.00
    Divin is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to...

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