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Cell Cycle

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  • (+/-) RK-682 | Tyrosine phopshatase inhibitor
    (+/-) RK-682 | Tyrosine phopshatase inhibitor
    $75.00
    RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7mu;M for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell...

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  • 10058-F4 | 403811-55-2 | Structure | Supplier
    10058-F4 | Myc inhibitor
    $50.00
    10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function1. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase...

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  • Alisertib | Potent and selective inhibitor of Aurora A / Destabilizes Myc
    Alisertib | Potent and selective inhibitor of Aurora A / Destabilizes Myc
    $60.00
    Alisertib (MLN8237, 1028486-01-2) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc...

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  • ALLN | Calpain inhibitor
    ALLN | Calpain inhibitor
    $50.00
    ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1 Inhibits cell cycle progression at G1/S and...

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  • Alsterpaullone | 237430-03-4 | Structure | Supplier
    Alsterpaullone | GSK3b inhibitor and CDK5/p25 inhibitor
    $56.00
    Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Alsterpaullone induces apoptosis2 and inhibits angiogenesis3...

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  • Aphidicolin | DNA polymerase inhibitor
    Aphidicolin | DNA polymerase inhibitor
    $70.00
    Aphidicolin (38966-21-1) specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at...

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  • Apicidin | HDAC inhibitor
    Apicidin | HDAC inhibitor
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

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  • Apigenin | 520-36-5 | Structure | Supplier
    Apigenin | Protein kinase inhibitor
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

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  • Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    $40.00
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

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  • BML-277 | 516480-79-8 | Structure | Supplier
    BML-277 | CHK2 inhibitor
    $90.00
    BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the...

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  • CFM-4 | 331458-02-7 | Structure | Supplier
    CFM-4 | CARP-1 mimetic
    $70.00
    CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM)1. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of...

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  • CI-994 | HDAC Inhibitor
    CI-994 | HDAC Inhibitor
    $65.00
    CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and...

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  • Colchicine | Microtubule depolymerizer
    Colchicine | Microtubule depolymerizer
    $40.00
    Colchicine (64-86-8) is a naturally occurring alkaloid which acts as an antimitotic agent by binding to tubulin and depolymerizing microtubules. Colchicine induces apoptosis in a variety of cell lines...

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  • Crizotinib | c-MET and ALK inhibitor
    Crizotinib | c-MET and ALK inhibitor
    $80.00
    Crizotinib (877399-52-5) is a potent and selective inhibitor of c-MET and ALK, IC50's=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of...

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  • Dasatinib | Src and Bcr/Abl inhibitor
    Dasatinib | Src and Bcr/Abl inhibitor
    $50.00
    Dasatinib (302962-49-8) inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively).1,2 Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell...

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  • Docetaxel | Microtubule stabilizing agent
    Docetaxel | Microtubule stabilizing agent
    $60.00
    Docetaxel (114977-28-5) is an antimitotic chemotherapeutic which inhibits via reversible high-affinity binding to microtubules1. Induces apoptosis in a variety of cancer cell lines2 however, tumor cells can quickly develop...

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  • Enzastaurin | PKC inhibitor
    Enzastaurin | PKC inhibitor
    $45.00
    Enzastaurin (170364-57-5) is a potent and selective PKCβ inhibitor.  IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell...

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  • Epothilone B | Microtubule stabilizing agent
    Epothilone B | Microtubule stabilizing agent
    $50.00
    Epothilone B (152044-54-7) induces microtubule polymerization. Causes cell cycle arrest at the G2-M transition (EC50 = 32 nM for HeLa cells). Induces apoptosis. Cell permeable. References/Citations1) Goodin et al. (2004),...

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  • Etoposide | 33419-42-0 | Structure | Supplier
    Etoposide | Topoisomerase II inhibitor
    $68.00
    Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Etoposide blocks the cell cycle in S-phase and...

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  • Fascaplysin | 114718-57-2 | Structure | Supplier
    Fascaplysin | CDK4 inhibitor
    $40.00
    Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1...

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