CANCER

Immunology

Stem Cells

Cell Death

Neurodegeneration

Cellular Stress

Inflammation

Proteasome

Diabetes

View All Physiological Processes & Diseases

Cell death can be divided in two major categories. Necrosis results from cellular injury caused by external factors such as trauma or infection. Programmed cell death is a regulated process that is mediated by various intracellular programs. Types of programmed cell death include apoptosis, anoikis, necroptosis, ferroptosis, pyroptosis, and parthanatos. These types of programmed cell death other than apoptosis have also been termed stress-induced cell death (SCID).

Apoptosis

Z-VAD-FMK

Cell permeable, irreversible, pan-caspase inhibitor

Staurosporine

Staurosporine is a pan-kinase inhibitor widely used to induce apoptosis

C2-Ceramide

Cell permeable ceramide analog that induces apoptosis in a wide variety of cell types

Obatoclax

Obatoclax is a pan-inhibitor of Bcl-2-family proteins

Ferroptosis

Erastin

Induces ferroptosis via inhibition of the cystine-glutamate antiporter, system Xc-

Ferrostatin-1

Ferrostatin-1 is a potent inhibitor of ferroptosis

Necroptosis

7-Cl-O-Nec1

Selective inhibitor of RIP1

GSK872

GSK872 is a potent and selective inhibitor of RIP3 that blocks necroptosis and necrosis

RIPA-56

Potent and selective inhibitor of RIP1

Necrosulfonamide

MLKL inhibitor that blocks necroptosis downstream of RIP3

Cell Death

New Products

BIOCHEMICAL TARGETS

Processes and Diseases

CUSTOM SYNTHESIS

CHEMICAL LIBRARIES

Update on the Latest Anti-SARS-CoV-2 Molecules

The emergence of SARS-CoV-2 has precipitated an unprecedented effort by the scientific community to find and develop potential therapeutics and...

REV-ERB agonists and Cancer

Researchers at the Salk Institute, the University of California, and the University of Texas have identified a potential new class of cancer...

SHP099 targets ALK inhibitor resistant cancer

Multiple cellular pathways can lead to acquired resistance to ALK inhibitors.  A common pathway is activation of alternate kinase pathways,...

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

®Copyright 2020 Focus Biomolecules. All Rights Reserved. Site by A.N. Creative