Programmed Cell Death

Cell death can be divided in two major categories. Necrosis results from cellular injury caused by external factors such as trauma or infection. Programmed cell death is a regulated process that is mediated by various intracellular programs. Types of programmed cell death include apoptosis, anoikis, necroptosis, ferroptosis, pyroptosis, and parthanatos. These types of programmed cell death other than apoptosis have also been termed stress-induced cell death (SCID).

Anoikis

  • R162 | Glutamate dehydrogenase 1 inhibitor
    CAS:
    64302-87-0
    Catalog Number:
    10-4603
    Activity:
    Glutamate Dehydrogenase 1 inhibitor
    Chemical Name:
    1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
    Alternate Names:
    Purpurin analog
    Molecular Weight:
    264.28
    Molecular Formula:
    C17H12O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml or in Ethanol (up to 5 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Anisomycin | Anoikis sensitizer
    CAS:
    22862-76-6
    Catalog Number:
    10-2056
    Activity:
    Anoikis sensitizer
    Chemical Name:
    (2R,3S,4S)-4-Hydroxy-2-)4-methoxybenzyl)pyrrolidin-3-yl acetate
    Molecular Weight:
    265.31
    Molecular Formula:
    C14H19NO4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
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Apoptosis

  • Violacein | Immunostimulant
    CAS:
    548-54-9
    Catalog Number:
    10-5073
  • Brefeldin A | Inhibits intracellular transport
    CAS:
    20350-15-6
    Catalog Number:
    10-1071
    Activity:
    Inhibits intracellular transport
    Alternate Names:
    Fermentation product from Penicillium brefeldianum
    Molecular Weight:
    280.37
    Molecular Formula:
    C16H24O4
    Solubility:
    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Okadaic acid | Protein phosphatase inhibitor
    CAS:
    78111-17-8
    Catalog Number:
    10-2091
    Activity:
    Protein phosphatase inhibitor
    Source:
    Isolated from marine dinoflagellates
    Molecular Weight:
    805.00
    Molecular Formula:
    C44H68O13
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Colchicine | Microtubule depolymerizer
    CAS:
    64-86-8
    Catalog Number:
    10-2310
    Activity:
    Microtubule depolymerizing agent
    Chemical Name:
    (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
    Molecular Weight:
    399.45
    Molecular Formula:
    C22H25NO6
    Solubility:
    Soluble in DMSO (up to 25 mg/ml), in Water (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White to pale-yellow solid
    Purity:
    99% by TLC/HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Leupeptin hemisulfate | Trypsin-like cysteine protease inhibitor
    CAS:
    103476-89-7
    Catalog Number:
    10-1346
    Activity:
    Trypsin-like cysteine protease inhibitor
    Alternate Names:
    Ac-Leu-Leu-Arg-CHO, hemisulfate
    Molecular Weight:
    475.59
    Molecular Formula:
    C20H38N6O4 &bul; 1/2H2SO4
    Solubility:
    Soluble in Water (up to 50 mg/ml). Also soluble in ethanol and methanol
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied Solutions in distilled water, ethanol or methanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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Ferroptosis

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Methuosis

  • MOMIPP | Methuosis inducer
    CAS:
    1363421-46-8
    Catalog Number:
    10-4766
    Activity:
    Methuosis Inducer
    Chemical Names:
    trans-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one
    Molecular Weight:
    292.33
    Molecular Formula:
    C18H16N2O2
    Solubility:
    Soluble in DMSO (7 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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Necroptosis

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Other Programmed Cell Death

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Paraptosis

  • Ophiobolin A | Autophagy inducer / Anticancer
    CAS:
    4611-05-6
    Catalog Number:
    10-3150
    Activity:
    Autophagy inducer / Anticancer
    Alternate Names:
    Cochliobolin A; Ophiobalin; NSC 114340
    Molecular Weight:
    400.55
    Molecular Formula:
    C25H36O4
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
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Pyroptosis

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