Chaperones
Calnexin/calreticulin Folding catalysts HSP31 HSP33 HSP60 HSP70 HSP90 HSP100 Other Chaperones Sigma receptor Small heat shock proteins All HSPs Heat Shock Proteins
Showing 1–12 of 27 results
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Angiogenesis
17-AAG | HSP90 inhibitor
17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and...$32.00 – $80.00 Select options -
Cellular Stress
17-AHA-Geldanamycin | Geldanamycin affinity chromatography ligand
17-AHA-geldanamycin is a semi-synthetic analog of geldanamycin containing a linker bearing a free NH2 functional group for conjugation. Selectively...$100.00 – $400.00 Select options -
Angiogenesis
17-DMAG | HSP90 inhibitor
17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and in...$32.00 – $80.00 Select options -
Cancer
17-GMP-APA-GA | Modified Geldanamycin
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immun...$140.00 – $500.00 Select options -
New Products
AR7 | Activates chaperone mediated autophagy
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pat...$70.00 – $280.00 Select options -
Cardioprotection
BGP-15 | Cellular protectant
BGP-15 (66611-37-8) is a cellular protectant operating by several mechanisms. It is an insulin sensitizer1, HSP72 activator2, PARP inhibitor and RO...$90.00 – $360.00 Select options -
New Products
BIIB021 | HSP90 Inhibitor
BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (I...$50.00 – $175.00 Select options -
New Products
CBL0137 | Inhibitor of the histone chaperone FACT
CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription...$80.00 – $295.00 Select options -
Alzheimers
Compound 115-7c | HSP70 modulator
Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the...$90.00 – $360.00 Select options -
Chaperones
DTG | High affinity sigma receptor agonist
DTG (97-39-2) is an agonist of the sigma (σ) receptor1 with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2. References/C...$30.00 – $45.00 Select options -
Addiction
GBR-12909 2HCl | Dopamine reuptake inhibitor
GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over seroto...$60.00 – $240.00 Select options -
Apoptosis
Geldanamycin | HSP90 inhibitor
Geldanamycin (30562-34-6) inhibits HSP90 by binding to its ATP-binding domain (Kd=1.2 μM) and subsequently inhibits HSP90 client proteins. Geldanam...$50.00 – $100.00 Select options
