PhysioProcesses

Disease Model Inducers

In addition to exploring signaling pathways, small molecules are also used as a means to an end: to create a cell or animal model system for further research or drug screening. Focus Biomolecules offers small molecule tools to induce model systems such as: Streptozotocin (diabetes, Alzheimer’s); Kainic acid (neurodegeneration); Bleomycin sulfate (pulmonary fibrosis); and many others to create cancer or stem cell models.

  • Monocrotaline | Induces pulmonary fibrosis

    CAS:
    315-22-0
    Catalog Number:
    10-2872
    Activity:
    Induces pulmonary fibrosis
    Chemical Name:
    (3R,4R,5R)-4,5,8,10,12,13,13aR,13bR-Octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
    Alternate Names:
    Crotaline; MCT; NSC28693
    Molecular Weight:
    325.36
    Molecular Formula:
    C16H23NO6
    Solubility:
    Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
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  • Ponasterone A | Insect steroid hormone

    CAS:
    13408-56-5
    Catalog Number:
    10-1404
    Activity:
    Insect steroid hormone
    Chemical Names:
    (5β)-2β,3β,14,20,22R-pentahydroxy-cholest-7-en-6-one
    Alternate Name:
    25-Deoxy-2-hydroxyecdysone; 25-deoxyecdysterone
    Molecular Weight:
    464.64
    Molecular Formula:
    C27H44O6
    Solubility:
    Soluble in DMSO (30 mg/ml); Ethanol (5 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >97% HPLC/TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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  • Puromycin Aminonucleoside | Nephropathy inducer

    CAS:
    58-60-6
    Catalog Number:
    10-2101
    Activity:
    Nephropathy inducer
    Alternate Names:
    PAN
    Chemical Name:
    3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
    Molecular Weight:
    294.32
    Molecular Formula:
    C12H18N6O3
    Solubility:
    Soluble in Water (up to 50 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
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  • Resiquimod | TLR7/8 agonist / Immune adjuvant

    CAS:
    144875-48-9
    Catalog Number:
    10-2733
    Activity:
    TLR7/8 agonist / Immune adjuvant
    Chemical Name:
    1-[4-Amino-2-ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
    Alternate Names:
    R848
    Molecular Weight:
    314.39
    Molecular Formula:
    C17H22N4O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
    From $65.00
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  • Rotenone | Mitochondrial Complex I Inhibitor

    CAS:
    83-79-4
    Catalog Number:
    10-2277
    Activity:
    Mitochondrial Complex I Inhibitor
    Chemical Names:
    (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
    Alternate Name:
    NSC-26285; Nicouline
    Molecular Weight:
    394.42
    Molecular Formula:
    C23H22O6
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room Temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $48.00
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  • Streptozotocin | Diabetes inducer

    CAS:
    18883-66-4
    Catalog Number:
    10-2127
    Activity:
    Diabetes inducer
    Chemical Name:
    2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
    Alternate Names:
    Streptozocin; U-9889
    Molecular Weight:
    265.22
    Molecular Formula:
    C8H15N3O7
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    97% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $100.00
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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