Intelliscreen™ Neuropathic Pain Ion Channel Mini-Library
Neuropathic pain is caused by damage or dysfunction to peripheral or central nervous system nerve fibers and is frequently chronic in nature. Persistent increased excitability and spontaneous activity in neurons leads to chronic pain that is difficult to treat. As the perception of pain is frequently transmitted via the activation of various ion channels, pharmacological modulation of these channels offers great therapeutic potential. The IntelliscreenTM Neuropathic pain ion channel mini-library contains blockers of various ion channels including sodium, calcium, TRP, P2X, NMDA, and AMPA that are involved in pain perception.
Catalog Number:
10-7310
Description:
12 inhibitors of various ion channels involved in pain transmission.
Solubility:
DMSO
Supplied As:
DMSO solution @ 10mM
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$400.00
In Stock
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
The Neuropathic Pain Ion Channels mini-library includes the following components for studying the important areas of this pathway.
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A-438079 HCl | P2X7 antagonist
From $60.00CAS:899431-18-6Catalog Number:10-4063Activity:P2X7 antagonistChemical Names:3-[5-(2,3-Dichlorophenyl)tetrazol-1-ylmethyl]pyridine hydrochlorideMolecular Weight:342.61Molecular Formula:C13H9Cl2N5·HClSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:White to off-white solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
A-803467 | NaV1.8 blocker
From $50.00CAS:944261-79-4Catalog Number:10-1066Activity:NaV1.8 blockerChemical Name:5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideMolecular Weight:357.8Molecular Formula:C19H16ClNO4Solubility:Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
A-967079 | TRPA1 blocker
From $50.00CAS:1170613-55-4Catalog Number:10-1055Activity:TRPA1 blockerChemical Name:(1E,3E)-1-(4-Fluorophenyl)-2-methylpent-1-en-3-one oximeMolecular Weight:207.25Molecular Formula:C12H14FNOSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT -
BAY-1797 | P2X4 antagonist
From $75.00CAS:2055602-83-8Catalog Number:10-3980Activity:P2X4 antagonistChemical Names:N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamideMolecular Weight:416.88Molecular Formula:C20H17ClN2O4SSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:Pale brown solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
D-AP5 | NMDA antagonist
CAS:79055-68-8Catalog Number:10-3940 -
HC-067047 | TRPV4 blocker
From $58.00CAS:883031-03-6Catalog Number:10-1480Activity:TRPV4 blockerChemical Name:2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamideMolecular Weight:471.51Molecular Formula:C26H28F3N3O2Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).Physical Properties:white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
ICA-121431 | Selective Sodium channel blocker
From $50.00CAS:313254-51-2Catalog Number:10-4085Activity:Selective Nav1.1/1.3 inhibitorChemical Names:2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamideMolecular Weight:449.54Molecular Formula:C23H19N3O3S2Solubility:Soluble in DMSO (>25 mg/ml)Physical Properties:Off-white to beige solidPurity:>98% TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
M8 B | TRPM8 blocker
CAS:883976-12-3Catalog Number:10-3997Molecular Weight:432.96 -
NS1209 | AMPA antagonist
CAS:245063-59-6Catalog Number:10-3934 -
PF-05089771 | Selective Nav1.7 inhibitor
From $60.00CAS:1235403-62-9Catalog Number:10-3990Activity:Selective Nav1.7 channel blockerChemical Name:4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamideAlternate Name:PF771Molecular Weight:500.34Molecular Formula:C18H12Cl2FN5O3S2Solubility:Soluble in DMSO (>25 mg/ml)Physical Properties:White solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
SB-705498 | TRPV1 blocker
From $65.00CAS:501951-42-4Catalog Number:10-3985Activity:TRPV1 blockerChemical Names:1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridine-2-yl]pyrrolidine-3-yl]ureaMolecular Weight:429.24Molecular Formula:C17H16BrF3N4OSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:White solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
TTA-P2 | Potent and selective T-type calcium channel antagonist
From $50.00CAS:918430-49-6Catalog Number:10-3993Activity:Selective T-type calcium channel antagonistChemical Names:(±)-3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamideMolecular Weight:431.37Molecular Formula:C21H29Cl2FN2O2Solubility:Soluble in DMSO (10 mg/ml)Physical Properties:Tan solidPurity:>97% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
