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Product Details

Pepstatin A | Aspartic protease inhibitor

Pepstatin A (26305-03-3) is a selective inhibitor of aspartyl proteases.1 Inhibits human pepsin, human gastricsin, renin, cathepsin D and E and bovine chymosin.2 Does not inhibit thiol proteases, neutral proteases or serine proteases.3 Pepstatin A suppresses RANKL-induced osteoclast differentiation.4

References/Citations

1) Merck Index 14:7147
2) Marciniszyn et al. (1976) Mode of inhibition of acid proteases by pepstatin; J. Biol. Chem., 251 7088
3) Oda (2012) New families of carboxy peptidases: serine-carboxyl peptidases and glutamic peptidases; J. Biochem., 151 13
4) Yoshida et al. (2006) Pepstatin A, an aspartic proteinase inhibitor, suppresses RANKL-induced osteoclast differentiation; J. Biochem., 139 583

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Focus Biomolecules cell signaling supplier, chemical structure of Pepstatin A | Aspartic protease inhibitor | CAS 26305-03-3

Catalog#  10-1368

$30.00
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CAS:
26305-03-3
Catalog Number:
10-1368
Activity:
Aspartic protease inhibitor
Chemical Name:
N-isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-γ-aminoheptanoyl-L-alanyl-3-hydroxy-6-methyl-γ-amino heptanoic acid
Molecular Weight:
685.90
Molecular Formula:
C34H63N5O9
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 1 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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