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Product Details

Phosphoramidon | Neutral endopeptidase inhibitor

Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC, Ki=2 nM.1 Also inhibits neprilysin 2 (Ki~2 nM).2 Also inhibits endothelin-converting enzyme (IC50 = 0.68 μM).3 Induces a dramatic increase in amyloid-beta levels in rodents.4


1) Stephenson and Kenny et al. (1987), The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J., 243 183.
2) Rose et al. (2002), Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J., 363 697
3) Ahn et al. (1998), Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys., 359 258
4) Marr and Hafez (2014), Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci., 6 187

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Catalog#  10-2548

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Catalog Number:
Neutral endopeptidase inhibitor
Chemical Name:
N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan • 2Na
Molecular Weight:
Molecular Formula:
C23H32N3O10P • 2Na
Soluble in DMSO, methanol, or distilled water
Physical Properties:
White solid
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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