Intelliscreen™ PI3K Inhibitors Mini-Library
Phosphatidylinositol 3-kinases (PI3K) are a family of lipid kinases that regulate various cellular processes including DNA repair, cell cycle, metabolism, senescence, and cell death. Aberrant PI3K function is implicated in a significant percentage of human cancers. The IntelliscreenTM PI3K Inhibitor mini-library includes compounds that target important kinases in this family: Class I PI3Ks (PI3Kα, PI3Kß, PI3Kγ, PI3Kδ) which catalyze the conversion of phosphatidylinositol (4,5)-bisphosphate to the triphosphate, class II (PIK3C2A, PIK3C2B, PIK3C2G) the conversion of phosphatidylinositol to the 3-phosphate and phosphatidyl 4-phosphate to the 3,4-diphosphate, and class III (PIK3C3 or Vps34) the conversion of phosphatidylinositol to the 3-phosphate.
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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
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GDC-0941 | pan-PI3K inhibitor
From $58.00CAS:957054-30-7Catalog Number:10-2141Activity:pan-Class I PI3-kinase inhibitorChemical Names:4-[2-(1H-Indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine; PictilisibMolecular Weight:513.64Molecular Formula:C23H27N7O3S2Solubility:Soluble in DMSO (>25 mg/ml)Physical Properties:White/off-white solidPurity:99% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
IPI-549 | Selective PI3Kgamma inhibitor / Immuno-oncology agent
From $50.00CAS:1693758-51-8Catalog Number:10-4827Activity:Selective PI3K-gamma inhibitor / Immuno-oncology agentChemical Name:(S)-2-Amino-N-[1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide; EganelisibMolecular Weight:629.68Molecular Formula:C30H24N8O2Solubility:Soluble in DMSO (up to at least 25 mg/ml)Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT
