BiochemicalTargets

CRISPR Reagents

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), originally found in prokaryotic genomes, is paired with Cas endonucleases to effect nucleotide insertions and deletions, enabling many applications that include DNA/RNA editing and diagnostics. Many related techniques continue to be developed and improved upon. Several small molecules reagents are available that enhance the overall efficiency and targeting precision of CRISPR/Cas9-mediated editing.

Efficiency enhancers

RS-1 | RAD51 activator / CRISPR enhancer

CAS:
312756-74-4
Catalog Number:
10-4099
Activity:
RAD51 activators / CRISPR enhancer
Chemical Name:
4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Molecular Weight:
524.23
Molecular Formula:
C20H16BrN2O3S
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Zidovudine | Antiretroviral / Enhances CRISPR repair

CAS:
30516-87-1
Catalog Number:
10-4615
Activity:
Antiretroviral / Enhances CRISPR repair
Chemical Names:
Azidothymidine; AZT
Molecular Weight:
267.24
Molecular Formula:
C10H13N5O4
Solubility:
Soluble in DMSO (>40 mg/ml); ethanol (>25 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT