Viral proteases

  • GRL-0617 | Potent SARS-CoV PLpro inhibitor

    CAS:
    1093070-16-6
    Catalog Number:
    10-4965
    Activity:
    Potent SARS-CoV PLpro inhibitor
    Chemical Name:
    5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
    Molecular Weight:
    304.39
    Molecular Formula:
    C20H20N2O
    Solubility:
    Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)
    Physical Properties:
    Beige solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20° (des.)
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $75.00
  • GRL-0667 | Noncovalent inhibitor of SARS-CoV PLpro

    CAS:
    1234195-91-5
    Catalog Number:
    10-4963
    Activity:
    Noncovalent SARS-CoV Plpro inhibitor
    Chemical Names:
    1-[(R)-1-(1-Naphthyl)ethyl)]-4-[3,4-(methylenedioxy)benzylamino]carbonylpiperidine
    Molecular Weight:
    416.52
    Molecular Formula:
    C26H28N2O3
    Solubility:
    Soluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $95.00
  • Nelfinavir mesylate | HIV protease inhibitor / Anticancer activity

    CAS:
    159989-65-8
    Catalog Number:
    10-3050
    Activity:
    HIV protease inhibtior / Anticancer activity
    Chemical Name:
    (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
    Alternate Name:
    AG-1343
    Molecular Weight:
    663.88
    Molecular Formula:
    C32H45N3O4S • CH3SO3H
    Solubility:
    Soluble in DMSO (up to 70 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $60.00
  • Ritonavir | HIV1/2 protease inhibitor

    CAS:
    155213-67-5
    Catalog Number:
    10-4484
    Activity:
    HIV 1/2 protease inhibitor
    Chemical Name:
    1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-2-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
    Molecular Weight:
    720.95
    Molecular Formula:
    C37H48N5O5S2
    Solubility:
    Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
    From $40.00
  • Telaprevir | Hepatitis C protease inhibitor

    CAS:
    402957-28-2
    Catalog Number:
    10-4929
    Activity:
    HCV protease inhibitor
    Chemical Names:
    (3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
    Alternate Name:
    VX-950
    Molecular Weight:
    679.86
    Molecular Formula:
    C36H53N7O6
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $50.00
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