p53 & Other Tumor Suppressors

  • PRIMA-1(MET) | Reactivates mutant p53

    CAS:
    5291-32-7
    Catalog Number:
    10-4175
    Activity:
    Reactivates mutant p53
    Chemical Name:
    2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
    Alternate Names:
    APR-246
    Molecular Weight:
    199.25
    Molecular Formula:
    C10H17NO3
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    95%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $50.00
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  • RITA | p53 Activator

    CAS:
    213261-59-7
    Catalog Number:
    10-3385
    Activity:
    p53 Activator
    Chemical Names:
    5,5′-(2,5-Furandiyl)bis-2-thiophenemethanol;
    NSC 652287
    Molecular Weight:
    292.37
    Molecular Formula:
    C14H12O3S2
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $70.00
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  • SL-01 | p53/mdm2 inhibitor

    CAS:
    26049-94-5
    Catalog Number:
    10-1326
    Activity:
    p53/mdm2 inhibitor
    Alternate Names:
    ZPCK
    Chemical Name:
    N-Benzyloxycarbonyl-L-phenylalaninylchloromethyl ketone
    Molecular Weight:
    331.8
    Molecular Formula:
    C18H18ClNO3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $30.00
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  • SR1078 | ROR agonist

    CAS:
    1246525-60-9
    Catalog Number:
    10-4066
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  • Tenovin-1 | SIRT1/2 inhibitor

    CAS:
    380315-80-0
    Catalog Number:
    10-2982
    Activity:
    SIRT1/2 Inhibitor
    Chemical Names:
    N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
    Molecular Weight:
    369.48
    Molecular Formula:
    C20H23N3O2S
    Solubility:
    Soluble in DMSO (10 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $40.00
    View Product This product has multiple variants. The options may be chosen on the product page
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