p53 & Other Tumor Suppressors
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Nutlin-3 | p53/mdm2 inhibitor
From $100.00CAS:548472-68-0Catalog Number:10-1350Activity:p53/mdm2 inhibitorChemical Name:(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-oneMolecular Weight:581.51Molecular Formula:C30H30Cl2N4O4Solubility:Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
Phenylhexyl isothiocyanate | Chemopreventive/HDAC inhibitor/p53 reactivator
CAS:133920-06-6Catalog Number:10-5258 -
PRIMA-1MET | Reactivates mutant p53
From $50.00CAS:5291-32-7Catalog Number:10-4175Activity:Reactivates mutant p53Chemical Name:2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-oneAlternate Names:APR-246Molecular Weight:199.25Molecular Formula:C10H17NO3Solubility:Soluble in DMSO (up to 20 mg/ml)Physical Properties:White solidPurity:95%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
RITA | p53 Activator
From $70.00CAS:213261-59-7Catalog Number:10-3385Activity:p53 ActivatorChemical Names:5,5′-(2,5-Furandiyl)bis-2-thiophenemethanol;
NSC 652287Molecular Weight:292.37Molecular Formula:C14H12O3S2Solubility:Soluble in DMSO (up to 20 mg/ml)Physical Properties:Yellow solidPurity:98% TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
EXPLORE OTHER Cancer
- ADC warheads
- Angiogenesis
- Autophagy
- Cancer Cell Metabolism
- Cancer Stem Cells
- Cell Cycle
- Cellular Stress
- Chemotherapeutics
- Cytoskeleton
- DNA Damage/Repair
- Drug resistance
- Epigenetics
- Gene Regulation/Transcription
- Growth factors
- Immuno-oncology
- Kinases
- Metastasis
- Other Cancer
- Programmed cell death
- Stem Cells
- Ubiquitin proteasome
- Wnt/ß-Catenin
