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Drug resistance

  • Bosutinib | Dual Src/Abl kinase inhibitor

    CAS:
    380843-75-4
    Catalog Number:
    10-2122
    Activity:
    Dual Src/Abl kinase inhibitor
    Chemical Names:
    4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
    Alternate Name:
    SKI-606
    Molecular Weight:
    530.45
    Molecular Formula:
    C26H29Cl2N5O3
    Solubility:
    Soluble in DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $40.00
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  • Brigatinib | pan-ALK inhibitor

    CAS:
    1197953-54-0
    Catalog Number:
    10-5034
    Activity:
    pan-ALK inhibitor
    Chemical Names:
    5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4- pyrimidinediamine
    Alternate Name:
    AP26113
    Molecular Weight:
    584.02
    Molecular Formula:
    C29H39ClN7O2P
    Solubility:
    Soluble in DMSO (1 mg/ml with warming)
    Physical Properties:
    White to off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
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  • Dubermatinib | AXL inhibitor

    Dubermatinib (1341200-45-0) is a potent (IC50 = 27 nM) inhibitor of the TAM family kinase AXL.1 It displayed potent activity against the pancreatic tumor cell line PSN-1 (IC50 = […]

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  • GAC Inhibitor 968 | Glutaminase C inhibitor

    CAS:
    311795-38-7
    Catalog Number:
    10-1538
    Activity:
    Glutaminase C inhibitor
    Chemical Names:

    5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]-phenanthridin-4(1H)-one

    Molecular Weight:
    475.42
    Molecular Formula:
    C27H27BrN2O
    Solubility:
    Soluble in DMSO (up to 11 mg/ml) or in Ethanol (up to 1 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98%  TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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  • Gambogic acid | Bcl-2 family/Survivin inhibitor

    CAS:
    2752-65-0
    Catalog Number:
    10-2188
    Activity:
    Bcl-2 family protein antagonist/Survivin inhibitor
    Molecular Weight:
    628.75
    Molecular Formula:
    C38H44O8
    Solubility:
    Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 50 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $60.00
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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