PhysioProcesses

Stem cells

Stem cells are unspecialized cells that can renew themselves via cell division and can differentiate to become tissue- or organ-specific cells. Embryonic stem cells are pluripotent – able to develop into any cell type in the human body. Adult or somatic stem cells are typically multipotent cells that are only able to differentiate into cells related to their tissue of origin. Induced pluripotent stem cells are adult stem cells that have been reprogrammed with various transcription factors to enable them to have embryonic stem cell-like properties. Many types of diseases and conditions that would benefit from the generation/regeneration of tissue are being investigated using stem cell-based therapies.

Dedifferentiation

  • Verteporfen | YAP Inhibitor
    CAS:
    129497-78-5
    Catalog Number:
    10-3487
    Activity:
    YAP inhibitor
    Chemical Names:
    (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
    Alternate Name:
    CL 318,952; BPD-MA
    Molecular Weight:
    718.79
    Molecular Formula:
    C41H42N4O8
    Solubility:
    Soluble in DMSO (up to 14 mg/ml)
    Physical Properties:
    Black solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Purmorphamine | Smoothened activator
    CAS:
    483367-10-8
    Catalog Number:
    10-4622
    Activity:
    Smoothened activator
    Chemical Name:
    1-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
    Molecular Weight:
    520.62
    Molecular Formula:
    C31H32N6O2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • RepSox | TGFß type I / ALK5 inhibitor
    CAS:
    446859-33-2
    Catalog Number:
    10-4546
    Activity:
    TGFß type I/ALK5 inhibitor
    Chemical Names:
    2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine; E-616452; SNJ 2511
    Molecular Weight:
    287.32
    Molecular Formula:
    C17H13N5
    Solubility:
    Soluble in DMSO (>25 mg/ml); ethanol (10 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • SMER-28 | Autophagy inducer
    CAS:
    307538-42-7
    Catalog Number:
    10-1287
    Activity:
    Autophagy inducer
    Chemical Name:
    6-Bromo-4-allylaminoquinazoline
    Molecular Weight:
    264.12
    Molecular Formula:
    C11H10BrN3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 2 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    CAS:
    13492-01-8
    Catalog Number:
    10-4535
    Activity:
    Demethylase inhibitor
    Chemical Name:
    trans-(±)-2-Phenylcyclopropylamine hemisulfate
    Molecular Weight:
    182.23
    Molecular Formula:
    C9H11N 1/2(H2SO4)
    Solubility:
    Soluble in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Dedifferentiation Products

Differentiation

  • IDE2 | Inducer of Definitive Endoderm
    CAS:
    1136466-93-7
    Catalog Number:
    10-4160
  • IDE1 | Inducer of Definitive Endoderm
    CAS:
    1160927-48-9
    Catalog Number:
    10-4159
  • TTNPB | Retinoid RAR agonist
    CAS:
    71441-28-6
    Catalog Number:
    10-2517
    Activity:
    Retinoid RAR agonist
    Chemical Names:
    4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
    Alternate Name:
    Ro 13-7410; AGN-191183
    Molecular Weight:
    348.49
    Molecular Formula:
    C24H28O3
    Solubility:
    Soluble in DMSO (4 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Nicotinamide | SIRT1 inhibitor/essential nutrient
    CAS:
    98-92-0
    Catalog Number:
    10-2840
    Activity:
    SIRT1 inhibitor/essential nutrient
    Chemical Names:
    Pyridine-3-carboxylic acid amide; Nicotinic acid amide; Niacinamide; Vitamin B3
    Molecular Weight:
    122.13
    Molecular Formula:
    C6H6N2O
    Solubility:
    Soluble in DMSO (50 mg/ml); water (50 ml)
    Physical Properties:
    White solid
    Purity:
    >99% HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BTB-1 | Mitotic kinesin Kif18A inhibitor
    CAS:
    86030-08-2
    Catalog Number:
    10-1543
    Activity:
    Mitotic kinesin Kif18A inhibitor
    Chemical Names:
    4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; NSC 156750
    Molecular Weight:
    297.71
    Molecular Formula:
    C12H8ClNO4S
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Differentiation Products

Generation

  • WS6 | Stimulates pancreatic ß-cell proliferation
    CAS:
    1421227-53-3
    Catalog Number:
    10-5666
  • GSK126 | EZH2 methyltransferase inhibitor
    CAS:
    1346574-57-9
    Catalog Number:
    10-3394
    Activity:
    EZH2 methyltransferase inhibitor
    Chemical Names:
    N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
    Molecular Weight:
    526.69
    Molecular Formula:
    C31H38N6O2
    Solubility:
    Soluble in DMSO (16 mg/ml)
    Physical Properties:
    Cream solid
    Purity:
    >98% HPLC/TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Chroman 1 | ROCK II inhibitor / Stem cell cytoprotectant
    CAS:
    1273579-40-0
    Catalog Number:
    10-4912
    Activity:
    ROCK II inhibitor / Stem cell cytoprotectant
    Chemical Names:
    (3S)-N-[2,[2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromen-3-carboxamide
    Molecular Weight:
    436.51
    Molecular Formula:
    C24H28N4O4
    Solubility:
    Soluble in DMSO (at least 50 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • HA-100·2HCl | Multi-kinase inhibitor
    CAS:
    85568-24-6
    Catalog Number:
    10-1609
    Activity:
    Multi-kinase inhibitor
    Chemical Names:
    5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride
    Molecular Weight:
    350.26
    Molecular Formula:
    C13H15N3O2S·2HCl
    Solubility:
    Soluble in DMSO (30 mg/ml); water (40 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Kenpaullone | GSK-3ß/CDK/KLF4 inhibitor
    CAS:
    142273-20-9
    Catalog Number:
    10-3028
    Activity:
    GSK-3ß/CDK/KLF4 inhibitor
    Chemical Names:
    9-Bromo-7,12-dihydro-indolo[3,2-d]benzazepine-6(5H)-one; NSC 664704
    Molecular Weight:
    327.18
    Molecular Formula:
    C16H11BrN2O
    Solubility:
    Soluble in DMSO (35 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Generation Products

Other Stem cells

  • BML-260 | JSP-1 phosphatase inhibitor
    CAS:
    101439-76-3
    Catalog Number:
    10-5153
    Activity:
    JSP-1 phosphatase inhibitor
    Chemical Names:
    (Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
    Molecular Weight:
    341.40
    Molecular Formula:
    C17H11NO3S2
    Solubility:
    Soluble in DMSO (45 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • UNC0224 | G9a histone methyl transferase inhibitor
    CAS:
    1197196-48-7
    Catalog Number:
    10-5216
  • A939572 | SCD1 inhibitor
    CAS:
    1032229-33-6
    Catalog Number:
    10-4639
    Activity:
    Potent SCD1 inhibitor
    Chemical Names:
    4-(2-Chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
    Molecular Weight:
    387.86
    Molecular Formula:
    C20H22ClN3O3
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • GW788388 | TGF-ß receptor kinase inhibitor
    CAS:
    452342-67-5
    Catalog Number:
    10-5521
    Activity:
    TGF-ß receptor kinase inhibitor
    Chemical Names:
    4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
    Molecular Weight:
    425.49
    Molecular Formula:
    C25H23N5O2
    Solubility:
    Soluble in DMSO (18 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Kenpaullone | GSK-3ß/CDK/KLF4 inhibitor
    CAS:
    142273-20-9
    Catalog Number:
    10-3028
    Activity:
    GSK-3ß/CDK/KLF4 inhibitor
    Chemical Names:
    9-Bromo-7,12-dihydro-indolo[3,2-d]benzazepine-6(5H)-one; NSC 664704
    Molecular Weight:
    327.18
    Molecular Formula:
    C16H11BrN2O
    Solubility:
    Soluble in DMSO (35 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Other Stem cells Products

Proliferation

  • PY-60 | YAP Activator
    CAS:
    2765218-56-0
    Catalog Number:
    10-3924
  • TPCA-1 | IkB kinase inhibitor
    CAS:
    507475-17-4
    Catalog Number:
    10-5571
    Activity:
    IkB kinase inhibitor
    Chemical Names:
    2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
    Molecular Weight:
    229.29
    Molecular Formula:
    C12H10FN3O4S
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Verteporfen | YAP Inhibitor
    CAS:
    129497-78-5
    Catalog Number:
    10-3487
    Activity:
    YAP inhibitor
    Chemical Names:
    (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
    Alternate Name:
    CL 318,952; BPD-MA
    Molecular Weight:
    718.79
    Molecular Formula:
    C41H42N4O8
    Solubility:
    Soluble in DMSO (up to 14 mg/ml)
    Physical Properties:
    Black solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Roxadustat | Prolyl hydroxylase domain inhibitor / HIF stabilizer
    CAS:
    808118-40-3
    Catalog Number:
    10-4468
    Activity:
    Prolyl hydroxylase domain inhibitor / HIF stabilizer
    Chemical Name:
    2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
    Alternate Name:
    FG-4592
    Molecular Weight:
    352.35
    Molecular Formula:
    C19H16N2O5
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Off-white or white solid
    Purity:
    99% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • CH-223191 | Arylhydrocarbon receptor antagonist
    CAS:
    301326-22-7
    Catalog Number:
    10-3089
    Activity:
    Arylhydrocarbon receptor antagonist
    Chemical Name:
    1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide
    Molecular Weight:
    333.39
    Molecular Formula:
    C19H19N5O
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Proliferation Products

Self renewal/maintenance

  • CPI203 | BET bromodomain inhibitor
    CAS:
    1446144-04-2
    Catalog Number:
    10-4048
  • Chroman 1 | ROCK II inhibitor / Stem cell cytoprotectant
    CAS:
    1273579-40-0
    Catalog Number:
    10-4912
    Activity:
    ROCK II inhibitor / Stem cell cytoprotectant
    Chemical Names:
    (3S)-N-[2,[2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromen-3-carboxamide
    Molecular Weight:
    436.51
    Molecular Formula:
    C24H28N4O4
    Solubility:
    Soluble in DMSO (at least 50 mg/ml)
    Physical Properties:
    White solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Emricasan | pan-Caspase inhibitor
    CAS:
    254750-02-2
    Catalog Number:
    10-4280
    Activity:
    pan-Caspase inhibitor
    Chemical Names:
    (3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
    Alternate Name:
    IDN-6556; PF-03491390
    Molecular Weight:
    569.51
    Molecular Formula:
    C26H27F4N3O7
    Solubility:
    Soluble in DMSO (20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • WH-4-023 | Src family kinase inhibitor
    CAS:
    837422-57-8
    Catalog Number:
    10-5124
    Activity:
    Src family kinase inhibitor
    Chemical Names:
    N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-carbamic acid 2,6-dimethylphenyl ester
    Molecular Weight:
    568.67
    Molecular Formula:
    C32H36N6O4
    Solubility:
    Soluble in DMSO (60 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
    Shipping Code:
    RT
  • EHNA HCl | PDE2 inhibitor
    CAS:
    51350-19-7
    Catalog Number:
    10-2438
    Activity:
    PDE2 inhibitor
    Chemical Names:
    Erythro-9-(2-hydroxy-3-nonyl)adenine, hydrochloride; NSC 263164
    Molecular Weight:
    318.87
    Molecular Formula:
    C14H28N5O ∙ HCl
    Solubility:
    Soluble in Water (up to 25 mg/ml)
    Physical Properties:
    Pale yellow or off-white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Self renewal/maintenance Products

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