Approved Drugs
Drugs approved by the FDA or other agencies for use in medicine are excellent tools for research because they are demonstrated to have good absorption (bioavailable), distribution and activity, and pharmacokinetics for use in vivo experiments. They are used in cells or animals for basic research, and for drug discovery (repurposing, benchmarking and other applications).
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Abemaciclib | Potent and selective CDK 4/6 inhibitor
From $50.00CAS:1231930-82-7Catalog Number:10-4833Activity:Potent and selective CDK 4/6 inhibitorChemical Name:N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridine-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine methanesulfonic acid saltAlternate Name:LY2835219 mesylateMolecular Weight:602.70Molecular Formula:C27H32F2N8 ∙ CH3SO3HSolubility:Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml).Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.Shipping Code:RT -
Acalabrutinib | Highly selective BTK inhibitor
From $45.00CAS:1420477-60-6Catalog Number:10-4806Alternate Name:ACP-196Activity:Highly selective BTK inhibitorChemical Name:4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamideMolecular Weight:465.52Molecular Formula:C26H23N7O2Solubility:Soluble in DMSO (up to at least 25 mg/ml)Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Actinomycin D | Transcription inhibitor
From $60.00CAS:50-76-0Catalog Number:10-2054Activity:Transcription inhibitorMolecular Weight:1255.42Molecular Formula:C62H86N12O16Solubility:Soluble in DMSO (50 mg/ml).Physical Properties:Orange-red solidPurity:>98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Protect from exposure to light and moisture. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.Shipping Code:RT -
Adapalene | Retinoid RARbeta, gamma agonist
From $30.00CAS:106685-40-9Catalog Number:10-1011Activity:Retinoid RARβ,γ agonistAlternate Names:CD271Chemical Name:6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acidMolecular Weight:412.53Molecular Formula:C28H28O3Solubility:Soluble in DMSO (up to 3 mg/ml) or in DMF (up to 6 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 monthsShipping Code:RT -
Afatinib | EGFR and HER2 inhibitor
From $45.00CAS:850140-72-6Catalog Number:10-4510Activity:EGFR and HER2 inhibitorChemical Name:N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2E-butenamideAlternate Names:BIBW2992Molecular Weight:485.94Molecular Formula:C24H25ClFN5O3Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Pale yellow solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
Alectinib | Potent and selective ALK inhibitor
From $60.00CAS:1256580-46-7Catalog Number:10-4793Activity:Potent and selective ALK inhibitorChemical Name:9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrileAlternate Name:CH5424802Molecular Weight:482.62Molecular Formula:C30H34N4O2Solubility:Soluble in DMSO (up to 5 mg/ml with warming).Physical Properties:White solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.Shipping Code:RT
