PhysioProcesses

Antivirals

Antivirals are used to treat viral infections by inhibiting the ability of the virus to infect cells or to propagate once in a cell. They are widely used to treat human and animal disease as well as in cell and human/animal research to study the pathways used for infection and propagation by viruses. Various antiviral agents may be used to block each step of infection, including fusion, entry, replication of viral components, viral assembly, and release.

Entry inhibitors

SSAA09E1 | SARS-CoV viral entry inhibitor

CAS:
433212-75-0
Catalog Number:
10-5075
Activity:
SARS-CoV viral entry inhibitor
Chemical Names:
[(Z)-1-Thiophene-2-ylethylideneamino]thiourea
Molecular Weight:
199.29
Molecular Formula:
C17H9N3S2
Solubility:
Soluble in DMSO (100 mg/ml); ethanol (10 mg/ml with warming
Physical Properties:
Beige solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years at-20°C from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Ki8751 | VEGFR2 inhibitor

CAS:
228559-41-9
Catalog Number:
10-4388
Activity:
VEGFR2 inhibitor
Chemical Names:
N-(2,4-Difluorophenyl)-N’-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
Molecular Weight:
469.42
Molecular Formula:
C24H18F3N3O4
Solubility:
Soluble in DMSO (15 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Emetine hydrochloride | Protein synthesis inhibitor

CAS:
316-42-7
Catalog Number:
10-3001
Activity:
Protein synthesis inhibitor
Chemical Names:
(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine dihydrochloride hydrate
Molecular Weight:
553.56
Molecular Formula:
C29H40N2O4·2HCl·XH2O
Solubility:
Soluble in Water (100 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
VIEW ALL Entry inhibitors​ PRODUCTS

Fusion inhibitors

Umifenovir | Broad-spectrum antiviral

CAS:
131707-23-8
Catalog Number:
10-4472
Activity:
Broad-spectrum antiviral
Chemical Name:
Ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate hydrochloride
Alternate Name:
Arbidol
Molecular Weight:
513.88
Molecular Formula:
C22H25BrN2O3S HCl
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Maraviroc | CCR5 Antagonist

CAS:
376348-65-1
Catalog Number:
10-4260
Activity:
CCR5 Antagonist
Chemical Name:
4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
Molecular Weight:
513.68
Molecular Formula:
C29H41F2N5O
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Alternate Name:
UK-427,857
VIEW ALL Fusion inhibitors​ PRODUCTS

Integrase inhibitors

Beauvericin | Disrupts mitochondrial volume

CAS:
26048-05-5
Catalog Number:
10-2061
Activity:
Disrupts mitochondrial volume
Chemical Names:
Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl]
Molecular Weight:
783.95
Molecular Formula:
C45H57N3O9
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
VIEW ALL Integrase inhibitors PRODUCTS

Neuraminidase inhibitors

Oseltamivir Phosphate | Neuraminidase inhibitor / Antiviral

CAS:
204255-11-9
Catalog Number:
10-4483
Activity:
Neuraminidase inhibitor / Antiviral
Chemical Name:
Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate phosphoric acid salt
Alternate Name:
GS4104; Tamiflu
Molecular Weight:
410.40
Molecular Formula:
C16H28N2O4•H3PO4
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Water (up to at least 40 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
VIEW ALL Neuraminidase inhibitors PRODUCTS

Polymerase inhibitors

Favipiravir | Inhibitor of viral RNA-dependent RNA polymerase

CAS:
259793-96-9
Catalog Number:
10-4471
Activity:
Inhibitor of viral RNA-dependent RNA polymerase
Chemical Name:
6-Fluoro-3-hydroxypyrazine-2-carboxamide
Alternate Name:
T-705
Molecular Weight:
157.10
Molecular Formula:
C5H4FN3O2
Solubility:
Soluble in DMSO (30 mg/mL), water (12 mg/mL with warming)
Physical Properties:
Off-white solid
Purity:
>99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or water may be stored at -20° for up to 3 months.
Shipping Code:
RT
VIEW ALL Polymerase inhibitors​ PRODUCTS

Protease inhibitors

Atazanavir | HIV protease inhibitor

CAS:
198904-31-3
Catalog Number:
10-5630
Activity:
HIV protease inhibitor
Chemical Names:
Methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
Alternate Name:
BMS 232632; CGP 73547; Latazanavir
Molecular Weight:
704.87
Molecular Formula:
C38H52N6O7
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Telaprevir | Hepatitis C protease inhibitor

CAS:
402957-28-2
Catalog Number:
10-4929
Activity:
HCV protease inhibitor
Chemical Names:
(3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
Alternate Name:
VX-950
Molecular Weight:
679.86
Molecular Formula:
C36H53N7O6
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Darunavir | HIV-1 protease inhibitor

CAS:
206361-99-1
Catalog Number:
10-4930
Activity:
HIV-1 protease inhibitor
Chemical Names:
[(3aS,4R,6aR)-2,3,3a,5,6a-Hexahydrofuro[2,3-b]furan-4-yl] N-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; UIC-94017; TMC114
Molecular Weight:
547.67
Molecular Formula:
C27H37N3O7S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
VIEW ALL Protease inhibitors PRODUCTS

Purine nucleosides

VIEW ALL Purine nucleosides PRODUCTS

Reverse transcriptase

Stavudine | HIV reverse transcriptase inhibitor

CAS:
3056-17-5
Catalog Number:
10-1266
Activity:
HIV reverse transcriptase inhibitor
Chemical Names:
2’,3’-Didehydro-3’-deoxythymidine
Alternate Name:
BMY 27857; d4T
Molecular Weight:
224.22
Molecular Formula:
C10H12N2O4
Solubility:
Soluble in DMSO (20 mg/ml); water (20 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Lamivudine | Reverse transcriptase inhibitor

CAS:
134678-17-4
Catalog Number:
10-2028
Activity:
Reverse transcriptase inhibitor
Chemical Names:
4-Amino-1-[(2R,5S)-2-(hydroxymethyl)1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Alternate Name:
(-)-BCH-189; 3TC
Molecular Weight:
229.25
Molecular Formula:
C8H11N3O3S
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Zidovudine | Antiretroviral / Enhances CRISPR repair

CAS:
30516-87-1
Catalog Number:
10-4615
Activity:
Antiretroviral / Enhances CRISPR repair
Chemical Names:
Azidothymidine; AZT
Molecular Weight:
267.24
Molecular Formula:
C10H13N5O4
Solubility:
Soluble in DMSO (>40 mg/ml); ethanol (>25 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
VIEW ALL Reverse transcriptase PRODUCTS

SARS-CoV2

Atazanavir | HIV protease inhibitor

CAS:
198904-31-3
Catalog Number:
10-5630
Activity:
HIV protease inhibitor
Chemical Names:
Methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
Alternate Name:
BMS 232632; CGP 73547; Latazanavir
Molecular Weight:
704.87
Molecular Formula:
C38H52N6O7
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Telaprevir | Hepatitis C protease inhibitor

CAS:
402957-28-2
Catalog Number:
10-4929
Activity:
HCV protease inhibitor
Chemical Names:
(3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
Alternate Name:
VX-950
Molecular Weight:
679.86
Molecular Formula:
C36H53N7O6
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Bedaquiline | Antituberculosis agent/bacterial ATP synthase inhibitor

CAS:
843663-66-1
Catalog Number:
10-4403
Activity:
Antituberculosis agent/Bacterial ATP synthase inhibitor
Chemical Names:
(1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-o
Alternate Name:
TMC207; R207910
Molecular Weight:
555.50
Molecular Formula:
C32H31BrN2O2
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
VIEW ALL SARS-CoV2 PRODUCTS

Other Antivirals

2E151 | Vaccine co-adjuvant

Vaccine adjuvants are materials that enhance the magnitude and duration of protective immune responses, typically via pattern recognition receptors (PRR).  2E151 (2416963-37-4) is a co-adjuvant that

Vesatolimod | TLR7 agonist/antiviral

CAS:
1228585-88-3
Catalog Number:
10-4921
Activity:
TLR7 agonist
Chemical Names:
4-Amino-2-butoxy-8-[[3-(pyrrolidine-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one
Alternate Name:
GS-9620
Molecular Weight:
410.52
Molecular Formula:
C22H30N6O2
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Nitazoxanide | Wnt signaling inhibitor

CAS:
55981-09-4
Catalog Number:
10-4633
Activity:
Wnt signaling inhibitor
Chemical Names:
O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate; NTZ
Molecular Weight:
307.28
Molecular Formula:
C12H9N3O5S
Solubility:
Soluble in DMSO (>50 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
VIEW ALL Other Antivirals PRODUCTS

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