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Bone and Connective Tissue

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  • Focus Biomolecules reagent supplier, chemical structure of 1,4-DPCA | Prolyl hydroxylase inhibitor | CAS 331830-20-7
    $60.00
    1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing...

  • Focus Biomolecules reagent supplier, chemical structure of 20(S)-Hydroxycholesterol | Smoothened activator | CAS 516-72-3
    $45.00
    20-(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Ansatrienin B | Cytotoxic activity | CAS 82189-04-6
    $345.00
    Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BADGE | PPAR gamma antagonist | CAS 1675-54-3
    $30.00
    BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional...

  • Focus Biomolecules cell signaling reagent supplier, structure of CHIR-99021 | GSK3 beta inhibitor | CAS 252917-06-9
    $70.00
    CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits...

  • Focus Biomolecules reagent supplier, chemical structure of Clodronate 2Na | Induces osteoclast apoptosis | CAS 88416-50-6
    $30.00
    Clodronate 2Na (88416-50-6) is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer.  It strongly binds to...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-2580 | cFMS kinase inhibitor | CAS 870483-87-7
    $72.00
    GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-9662 | PPAR gamma antagonist | CAS 22978-25-2
    $30.00
    GW-9662 (22978-25-2) is a selective PPARγ antagonist (IC50 = 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively)1. Blocks the inhibition of osteoclast formation induced by IL-4 (1-2 μM)2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Harmine | MAO-A and DYRK inhibitor | CAS 343-27-1
    $25.00
    Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50 = 8 μM).1 Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation...

  • Focus Biomolecules supplier, chemical structure Ibandronate | Farnesyl pyrophosphatase synthase inhibitor | CAS 138926-19-9
    $30.00
    Ibandronate (138926-19-9) is a clinically useful drug for the prevention and treatment of osteoporosis and skeletal fractures in patients with cancer.  It is a potent inhibitor of farnesyl pyrophosphate synthase (IC50 =...

  • Focus Biomolecules supplier, chemical structure of Kartogenin | Induces chrondrocyte differentiation | CAS 4727-31-5
    $48.00
    Kartogenin (4727-31-5) promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Kartogenin displays chrondroprotective effects in vitro and is efficacious in two animal...

  • Focus Biomolecules cell signaling supplier, chemical structure of LDN-193189 | ALK2 &  ALK3 inhibitor | CAS 1062368-62-0
    $70.00
    LDN-193189 HCl (1062368-62-0) is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1  Only weak inhibition of ALK4, ALK5, and ALK7 is observed...

  • Focus Biomolecules reagent supplier, chemical structure of Salubrinal | eIF2a Phosphatase inhibitor | CAS 405060-95-9
    $80.00
    Salubrinal (405060-95-9) is an endoplasmic reticulum (ER) stress inhibitor. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been...

  • Focus Biomolecules supplier, chemical structure of SB 203580 | p38 MAP kinase inhibitor | CAS 152121-47-6
    $75.00
    SB 203580 (152121-47-6) is a potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and...

  • Focus Biomolecules cell signaling supplier, chemical structure of Z-Phe-Tyr-CHO | Cathepsin L inhibitor | CAS 167498-29-5
    $30.00
    A potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over  cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic  pit formation at 1.5 nM and markedly...

  • Focus Biomolecules supplier, chemical structure Zoledronic acid | Antiproliferative and apopototic effects | CAS 118072-93-8
    $45.00
    Zoledronic acid (118072-93-8) is a potent inhibitor of bone resorption (IC50 = 2 nM in mouse calvarial cultures).1 The mechanism of its action is thought to be via inhibition of osteoclastic activity, induction of osteoclast...

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