Bone and Connective Tissue
Showing 1–12 of 17 results
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Bone and Connective Tissue
1,4-DPCA | Prolyl hydroxylase inhibitor
1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM)1. Inhibits collagen deposition via inhibition of collagen prolin...$60.00 – $220.00 Select options -
Bone and Connective Tissue
Ansatrienin B | Cytotoxic activity
Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several cli...$345.00 Select options -
Adipogenesis
BADGE | PPAR gamma antagonist
BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes th...$30.00 – $100.00 Select options -
Adipogenesis
CHIR-99021 | GSK3 beta inhibitor
CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces...$70.00 – $295.00 Select options -
Approved Drugs
Clodronate 2Na | Induces osteoclast apoptosis
Clodronate 2Na (88416-50-6) is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal...$30.00 – $70.00 Select options -
Arthritis
GW-2580 | cFMS kinase inhibitor
GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity agai...$72.00 – $288.00 Select options -
Bone and Connective Tissue
GW-9662 | PPAR gamma antagonist
GW-9662 (22978-25-2) is a selective PPARγ antagonist (IC50 = 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively)1. Blocks the inhibition o...$30.00 – $100.00 Select options -
Antifungals
Harmine | MAO-A and DYRK inhibitor
Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50 = 8 μM).1 Harmine is a potent and specific inhibitor of both ...$25.00 – $50.00 Select options -
Approved Drugs
Ibandronate | Farnesyl pyrophosphatase synthase inhibitor / osteoporosis drug
Ibandronate (138926-19-9) is a clinically useful drug for the prevention and treatment of osteoporosis and skeletal fractures in patients with canc...$30.00 – $100.00 Select options -
Bone and Connective Tissue
Kartogenin | Induces chrondrocyte differentiation
Kartogenin (4727-31-5) promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Kartogenin d...$48.00 – $192.00 Select options