Bone and Connective Tissue

Diseases of bone (such as osteoporosis) and connective tissue (rheumatoid arthritis, lupus) can be studied in cell and animal models with small molecules that regulate immunity, inflammation, protein folding, and certain key kinases like JAK.

  • GW-2580 | cFMS kinase inhibitor

    CAS:
    870483-87-7
    Catalog Number:
    10-2143
    Activity:
    cFMS kinase inhibitor
    Chemical Name:
    5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
    Molecular Weight:
    366.32
    Molecular Formula:
    C20H22N4O3
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $72.00
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  • GW-9662 | PPAR gamma antagonist

    CAS:
    22978-25-2
    Catalog Number:
    10-2622
    Activity:
    PPAR gamma antagonist
    Chemical Name:
    2-Chloro-5-nitrobenzanilide
    Molecular Weight:
    276.68
    Molecular Formula:
    C13H9ClN2O3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $45.00
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  • Harmine | MAO-A and DYRK inhibitor

    CAS:
    343-27-1
    Catalog Number:
    10-4520
    Activity:
    MAO-A and DYRK inhibitor
    Chemical Name:
    7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride
    Molecular Weight:
    248.71
    Molecular Formula:
    C13H12N2O HCl
    Solubility:
    Soluble in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    >98% by TLC
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $25.00
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  • Ibandronate | Farnesyl pyrophosphatase synthase inhibitor / osteoporosis drug

    CAS:
    138926-19-9
    Catalog Number:
    10-4630
    Activity:
    Farnesyl pyrophosphatase synthase inhibitor / osteoporosis drug
    Chemical Name:
    (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium monohydrate
    Molecular Weight:
    359.23
    Molecular Formula:
    C9H22NO7P2•Na • H2O
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $30.00
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  • Kartogenin | Induces chrondrocyte differentiation

    CAS:
    4727-31-5
    Catalog Number:
    10-1372
    Activity:
    Induces chrondrocyte differentiation
    Chemical Name:
    2-[(1,1′-Biphenyl)-4-ylcarbamoyl]benzoic acid
    Molecular Weight:
    317.35
    Molecular Formula:
    C20H15NO3
    Solubility:
    Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 14 mg/ml).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $50.00
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  • LDN-193189 | Inhibitor of ALK2 and ALK3

    CAS:
    1435934-00-1
    Catalog Number:
    10-4764
    Activity:
    Inhibitor of ALK2 and ALK3
    Chemical Name:
    4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline dihydrochloride
    Molecular Weight:
    479.40
    Molecular Formula:
    C25H22N6·2HCl
    Solubility:
    Soluble in DMSO or in Water (up to 5 mg/ml)
    Physical Properties:
    Orange-yellow solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
    From $60.00
    View Product This product has multiple variants. The options may be chosen on the product page
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