Bone and Connective Tissue

Diseases of bone (such as osteoporosis) and connective tissue (rheumatoid arthritis, lupus) can be studied in cell and animal models with small molecules that regulate immunity, inflammation, protein folding, and certain key kinases like JAK.

  • 1,4-DPCA | Prolyl hydroxylase inhibitor

    CAS:
    331830-20-7
    Catalog Number:
    10-2956
    Activity:
    Prolyl hydroxylase inhibitor
    Chemical Name:
    1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid
    Molecular Weight:
    240.22
    Molecular Formula:
    C13H8N2O3
    Solubility:
    Soluble in DMSO (up to 15 mg/ml with warming).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
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  • 20(S)-Hydroxycholesterol | Smoothened activator

    CAS:
    516-72-3
    Catalog Number:
    10-4540
    Activity:
    Smoothened activator
    Chemical Name:
    5-Cholesten-3β, 20α-diol
    Molecular Weight:
    402.66
    Molecular Formula:
    C27H46O2
    Solubility:
    Soluble in DMSO or in Ethanol.
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $40.00
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  • Ansatrienin B | Cytotoxic activity

    CAS:
    82189-04-6
    Catalog Number:
    10-1576
    Activity:
    Cytotoxic activity
    Alternate Names:
    Mycotrienin II; Antibiotic T2311
    Source:
    Fermentation product from Streptomyces sp.
    Molecular Weight:
    638.87
    Molecular Formula:
    C36H50N2O8
    Solubility:
    Soluble in DMSO, DMF, Ethanol or Methanol
    Physical Properties:
    Pale-yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $100.00
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  • BADGE | PPAR gamma antagonist

    CAS:
    1675-54-3
    Catalog Number:
    10-2618
    Activity:
    PPARγ antagonist
    Chemical Name:
    2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane
    Alternate Names:
    Bisphenol A diglycidyl ether
    Molecular Weight:
    340.41
    Molecular Formula:
    C21H24O4
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml)
    Physical Properties:
    White low melting point solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $30.00
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  • Clodronate 2Na | Induces osteoclast apoptosis

    CAS:
    88416-50-6
    Catalog Number:
    10-4631
    Activity:
    Induces osteoclast apoptosis
    Chemical Name:
    Dichloromethylenediphosphonic acid disodium tetrahydrate
    Molecular Weight:
    360.92
    Molecular Formula:
    CH2Cl2O6P2·2Na·4H2O
    Solubility:
    Soluble in Water (up to at least 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $30.00
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  • DY131 | Estrogen-related receptor ERRbeta and ERRgamma agonist

    CAS:
    95167-41-2
    Catalog Number:
    10-1561
    Activity:
    Estrogen-related receptor ERRbeta and ERRgamma agonist
    Chemical Name:
    N-(4-(Diethylaminobenzylidenyl)-N’-(4-hydroxybenzoyl)-hydrazine
    Alternate Name:
    GSK-9089
    Molecular Weight:
    311.38
    Molecular Formula:
    C18H21N3O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $42.00
    View Product This product has multiple variants. The options may be chosen on the product page
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