27-Hydroxycholesterol | Cholesterol oxidation metabolite

CAS:
20380-11-4
Catalog Number:
10-4536
Activity:
Cholesterol oxidation metabolite
Chemical Name:
27-Hydroxycholesterol; 5,25R-Cholesten-3β,26-diol
Molecular Weight:
402.66
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

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1 mg$40.00
5 mg$170.00
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27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimer’s disease and mild cognitive impairment.1,2 Endogenous selective estrogen receptor modulator3 and ligand for the liver X receptor(EC50M = 85nM for LXR7alpha; and 71nM for LXRβ)4.

References/Citations:

1) Heverin et al. (2004), Changes in the levels of cerebral and extracerebral sterols in the brains of patients with Alzheimer’s disease; J. Lipid Res., 45 186
2) Shafaati et al. (2011), Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer’s patients with the Swedish APP 670-671 mutation; J. Lipid Res., 52 1004
3) Umetani et al. (2007), 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen; Nature Medicine, 13 1185
4) Fu et al. (2001), 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells; J. Biol.Chem., 276 38378

CAS:
20380-11-4
Catalog Number:
10-4536
Activity:
Cholesterol oxidation metabolite
Chemical Name:
27-Hydroxycholesterol; 5,25R-Cholesten-3β,26-diol
Molecular Weight:
402.66
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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