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  • 4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
    4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
    $125.00
    4,9-Anhydrotetrodotoxin (13072-89-4) is a highly selective blocker of the Na(v1.6) sodium channel. (IC50's: Na(v1.2) = 260 nM, Na(v1.3) = 341 nM, Na(v1.4) = 988 nM, Na(v1.5) = 11.6 μM, Na(v1.6) = 7.8 nM, Na(v1.7) = 1.27...

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  • 5alpha,6alpha-Epoxycholesterol | LXR ligand
    5alpha,6alpha-Epoxycholesterol | LXR ligand
    $25.00
    5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol.  It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3...

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  • Actinomycin D | Transcription inhibitor
    Actinomycin D | Transcription inhibitor
    $50.00
    Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase.1 Induces apoptosis in a variety of cancer cell...

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  • Alamethicin | Pore-forming antimicrobial peptide
    Alamethicin | Pore-forming antimicrobial peptide
    $35.00
    Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, permeabilization of sarcoplasmic reticulum vesicles3 and mitochondria4 and...

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  • Alpha-Mangostin | STING agonist (human)
    Alpha-Mangostin | STING agonist (human)
    $50.00
    α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates...

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  • Andrographolide | 5508-58-7 | Structure | Supplier
    Andrographolide | Induces mitochondrial -mediated apoptosis in lymphoma cells
    $34.00
    Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo...

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  • Anisomycin | Anoikis sensitizer
    Anisomycin | Anoikis sensitizer
    $35.00
    Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable. References/Citations1) Hazzalin et al...

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  • Ansamitocin P3 | Microtubule depolymerizer
    Ansamitocin P3 | Microtubule depolymerizer
    $100.00
    Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin.1,2 Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity...

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  • Ansatrienin B | Cytotoxic activity
    Ansatrienin B | Cytotoxic activity
    $345.00
    Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1...

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  • Antibiotic A-23187 | Ca2+ ionophore
    Antibiotic A-23187 | Ca2+ ionophore
    $90.00
    Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative...

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  • Aphidicolin | DNA polymerase inhibitor
    Aphidicolin | DNA polymerase inhibitor
    $70.00
    Aphidicolin (38966-21-1) specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at...

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  • Apicidin | HDAC inhibitor
    Apicidin | HDAC inhibitor
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

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  • Apigenin | 520-36-5 | Structure | Supplier
    Apigenin | Protein kinase inhibitor
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

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  • Apoptolidin | Apoptosis inducer
    Apoptolidin | Apoptosis inducer
    $248.00
    Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1 Is believed to act via inhibition of F0F1-ATPase2 but correlation studies indicate that a second mechanism may be the actual...

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  • Arecoline HBr | ACAT1 inhibitor
    Arecoline HBr | ACAT1 inhibitor
    $30.00
    Arecoline (300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA...

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  • Ascomycin | FKBP ligand immunosuppressant
    Ascomycin | FKBP ligand immunosuppressant
    $35.00
    Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays antiinflammatory effects in skin diseases3. Cell permeable and...

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  • Aspterric acid | Plant growth regulator
    Aspterric acid | Plant growth regulator
    $100.00
    Aspterric acid (67309-95-9) is a fungal sequeterpenoid1 plant growth inhibitor discovered using a resistance-gene-directed approach.1 It is an inhibitor of dihydroxy-acid dehydratase (DHAD, IC50=0.31 and 0.5 μM for...

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  • Bafilomycin A1 | Vacuolar H+ ATPase inhibitor
    Bafilomycin A1 | Vacuolar H+ ATPase inhibitor
    $80.00
    Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via...

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  • Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    $40.00
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

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  • Bakuchiol | Antioxidant
    Bakuchiol | Antioxidant
    $0.00
    Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.1 Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2 Protects against acute lung injury...

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