PhysioProcesses

Obesity and metabolic diseases

Obesity and other metabolic disorders (such as fatty liver disease) are closely linked to diabetes, which in turn is tightly associated with glucose and fatty acid metabolism, circadian clock, mitochondrial function, inflammation, and many others. Focus Biomolecules offers many inhibitors and other modulators of the pathways involved in these processes.

Metabolic syndrome

View All Metabolic syndrome Products

NASH/NAFLD

  • BI01383298 | Citrate transporter inhibitor
    CAS:
    2227549-00-8
    Catalog Number:
    10-4191
  • GSK620 | BD2 selective BET inhibitor
    CAS:
    2088410-46-0
    Catalog Number:
    10-4180
  • DT-109 | Induces glutathione biosynthesis
    CAS:
    14857-82-0
    Catalog Number:
    10-5732
    Activity:
    Induces glutathione biosynthesis
    Chemical Names:
    Glycyl-glycyl-L-leucine; Gly-Gly-Leu-OH
    Molecular Weight:
    245.28
    Molecular Formula:
    C10H19N3O4
    Solubility:
    Soluble in DMSO (25 mg/ml with warming); Water (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Firsocostat | Allosteric acetyl-CoA carboxylase inhibitor
    CAS:
    1434635-54-7
    Catalog Number:
    10-4699
    Activity:
    Allosteric ACC inhibitor
    Chemical Names:
    2-[1-[(2R)-2-(2-Methoxyphenyl)-2-9oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid
    Alternate Name:
    ND-630; NDI-010976; GS-0976
    Molecular Weight:
    569.63
    Molecular Formula:
    C28H31N3O8S
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Oltipraz | Nrf2 activator
    CAS:
    64224-21-1
    Catalog Number:
    10-2831
    Activity:
    Nrf2 activator
    Chemical Name:
    4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
    Molecular Weight:
    226.34
    Molecular Formula:
    C8H6N2S3
    Solubility:
    Soluble in DMSO (up to 50 mg/ml).
    Physical Properties:
    Red solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All NASH/NAFLD Products

Other metabolic diseases

  • Migalastat HCl | Galactosidase inhibitor/Pharmacological chaperone
    CAS:
    75172-81-5
    Catalog Number:
    10-2632
  • KY-226 | PTP1B inhibitor
    CAS:
    1621673-53-7
    Catalog Number:
    10-4004
    Activity:
    PTP1B Inhibitor
    Chemical Name:
    4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide
    Molecular Weight:
    481.67
    Molecular Formula:
    C27H31NO3S2
    Solubility:
    Soluble in DMSO (>25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    >98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Miglustat HCl | Alpha-glucosidase inhibitor
    CAS:
    210110-90-0
    Catalog Number:
    10-2413
    Activity:
    Alpha-glucosidase inhibitor
    Chemical Name:
    N-Butyldeoxynojirimycin HCl
    Alternate Names:
    NB-DNJ
    Molecular Weight:
    255.74
    Molecular Formula:
    C10H21NO4 • HCL
    Solubility:
    Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Isofagomine tartrate | Glucocerebrosidase activator and chaperone
    CAS:
    957230-65-8
    Catalog Number:
    10-2859
    Activity:
    Glucocerebrosidase activator and chaperone
    Chemical Name:
    (3R,4R,5R)-5-Hydroxymethyl-3,5-piperidinediol tratrate
    Molecular Weight:
    297.26
    Molecular Formula:
    C6H13NO3 • C4H6O6
    Solubility:
    Soluble in DMSO (up to 2 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Cerulenin | Fatty acid synthase inhibitor
    CAS:
    17397-89-6
    Catalog Number:
    10-2062
    Activity:
    Fatty Acid Synthase inhibitor
    Chemical Name:
    2,3-Epoxy-4-oxo-7,10-dodecadienamide
    Molecular Weight:
    223.27
    Molecular Formula:
    C12H17NO3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Other metabolic diseases Products

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Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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