Disease Model Inducers
In addition to exploring signaling pathways, small molecules are also used as a means to an end: to create a cell or animal model system for further research or drug screening. Focus Biomolecules offers small molecule tools to induce model systems such as: Streptozotocin (diabetes, Alzheimer’s); Kainic acid (neurodegeneration); Bleomycin sulfate (pulmonary fibrosis); and many others to create cancer or stem cell models.
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Kainic acid | Kainate receptor agonist/neurotoxin
From $120.00CAS:487-79-6Catalog Number:10-2453Activity:Kainate receptor agonist; neurotoxinChemical Name:(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid, hydrateMolecular Weight:213.24Molecular Formula:C10H15NO4 (xH2O)Solubility:Soluble in Water (up to 10 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.Shipping Code:RT -
Monocrotaline | Induces pulmonary fibrosis
From $50.00CAS:315-22-0Catalog Number:10-2872Activity:Induces pulmonary fibrosisChemical Name:(3R,4R,5R)-4,5,8,10,12,13,13aR,13bR-Octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dioneAlternate Names:Crotaline; MCT; NSC28693Molecular Weight:325.36Molecular Formula:C16H23NO6Solubility:Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
Ponasterone A | Insect steroid hormone
From $50.00CAS:13408-56-5Catalog Number:10-1404Activity:Insect steroid hormoneChemical Names:(5β)-2β,3β,14,20,22R-pentahydroxy-cholest-7-en-6-oneAlternate Name:25-Deoxy-2-hydroxyecdysone; 25-deoxyecdysteroneMolecular Weight:464.64Molecular Formula:C27H44O6Solubility:Soluble in DMSO (30 mg/ml); Ethanol (5 mg/ml with warming)Physical Properties:White solidPurity:>97% HPLC/TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Puromycin Aminonucleoside | Nephropathy inducer
From $60.00CAS:58-60-6Catalog Number:10-2101Activity:Nephropathy inducerAlternate Names:PANChemical Name:3′-Amino-3′-deoxy-N6,N6-dimethyladenosineMolecular Weight:294.32Molecular Formula:C12H18N6O3Solubility:Soluble in Water (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.Shipping Code:RT -
Resiquimod | TLR7/8 agonist / Immune adjuvant
From $65.00CAS:144875-48-9Catalog Number:10-2733Activity:TLR7/8 agonist / Immune adjuvantChemical Name:1-[4-Amino-2-ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-olAlternate Names:R848Molecular Weight:314.39Molecular Formula:C17H22N4O2Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml with warming)Physical Properties:White solidPurity:>98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT
