Metals and biological systems

Many enzymes and systems depend on metal ions, such as zinc, iron, and copper, for proper function. These include proteases (active site function), hemoglobins (carrying oxygen), cytochromes (electron transfer), free radical control, and metal ion storage. Chelators sequester metal ions, offering a way to control or block these functions, which can be useful in infectious disease, wound healing, and heavy metal poisoning, and research in metal-dependent processes such as ferroptosis, cuproptosis, and oxidative stress.

  • Divin | Divisome assembly inhibitor

    CAS:
    1443321-11-6
    Catalog Number:
    10-4105
    Activity:
    Divisome assembly inhibitor
    Chemical Name:
    N’-[(E)-(2-Hydroxynaphthalen-1-yl)methylidene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide
    Molecular Weight:
    372.42
    Molecular Formula:
    C22H20N4O2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $75.00
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  • Dp44mT | Metal chelator

    CAS:
    152095-12-0
    Catalog Number:
    10-4951
    Activity:
    Metal chelator
    Chemical Name:
    3-(Dipyridin-2-ylmethylideneamino)-1,1-dimethylthiourea
    Molecular Weight:
    285.37
    Molecular Formula:
    C14H15N5S
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may ne stored at -20°C for 1 month.
    Shipping Code:
    RT
    From $35.00
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  • Elesclomol supplier | CAS 488832-69-5 | Focus Biomolecules

    Elesclomol | Copper chelator/Cuproptosis inducer

    CAS:
    488832-69-5
    Catalog Number:
    10-4238
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  • Eltrombopag | Small molecule thrombopoietin agonist

    CAS:
    496775-61-2
    Catalog Number:
    10-3768
    Activity:
    Small molecule thrombopoietin agonist
    Chemical Name:
    3’-[2-[(2Z)-1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2’-hydroxy-[1,1’-biphenyl]-3-carboxylic acid
    Alternate Name:
    SB-497115
    Molecular Weight:
    442.47
    Molecular Formula:
    C25H22N4O4
    Solubility:
    Soluble in DMSO (up to 55 mg/ml) or in ethanol (up to 14 mg/ml).
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $55.00
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  • Erastin | Ferroptosis inducer

    CAS:
    571203-78-6
    Catalog Number:
    10-3406
    Activity:
    Ferroptosis inducer
    Chemical Name:
    2-[1-[4-[2-(4-Chlorophenyoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
    Molecular Weight:
    547.04
    Molecular Formula:
    C30H34ClN4O4
    Solubility:
    Soluble in DMSO (up to 10 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $65.00
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  • Ferrioxamine E | Siderophore

    CAS:
    20008-20-2
    Catalog Number:
    10-5156
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