Metals and biological systems
Many enzymes and systems depend on metal ions, such as zinc, iron, and copper, for proper function. These include proteases (active site function), hemoglobins (carrying oxygen), cytochromes (electron transfer), free radical control, and metal ion storage. Chelators sequester metal ions, offering a way to control or block these functions, which can be useful in infectious disease, wound healing, and heavy metal poisoning, and research in metal-dependent processes such as ferroptosis, cuproptosis, and oxidative stress.
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Dp44mT | Metal chelator
From $25.00CAS:152095-12-0Catalog Number:10-4951Activity:Metal chelatorChemical Name:3-(Dipyridin-2-ylmethylideneamino)-1,1-dimethylthioureaMolecular Weight:285.37Molecular Formula:C14H15N5SSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may ne stored at -20°C for 1 month.Shipping Code:RT -
Eltrombopag | Small molecule thrombopoietin agonist
From $55.00CAS:496775-61-2Catalog Number:10-3768Activity:Small molecule thrombopoietin agonistChemical Name:3’-[2-[(2Z)-1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2’-hydroxy-[1,1’-biphenyl]-3-carboxylic acidAlternate Name:SB-497115Molecular Weight:442.47Molecular Formula:C25H22N4O4Solubility:Soluble in DMSO (up to 55 mg/ml) or in ethanol (up to 14 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Erastin | Ferroptosis inducer
From $65.00CAS:571203-78-6Catalog Number:10-3406Activity:Ferroptosis inducerChemical Name:2-[1-[4-[2-(4-Chlorophenyoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinoneMolecular Weight:547.04Molecular Formula:C30H34ClN4O4Solubility:Soluble in DMSO (up to 10 mg/ml with warming)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Ferrostatin-1 | Ferroptosis inhibitor
From $45.00CAS:347174-05-4Catalog Number:10-1380Activity:Ferroptosis inhibitorChemical Name:Ethyl 3-amino-4-(cyclohexylamino)benzoateMolecular Weight:262.35Molecular Formula:C15H22N2O2Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).Physical Properties:Tan solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
Hinokitiol | Iron Chelator antioxidant
From $52.00CAS:499-44-5Catalog Number:10-2211Activity:Iron Chelator antioxidantAlternate Names:β-ThujaplicinChemical Name:2-Hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-oneMolecular Weight:164.2Molecular Formula:C10H12O2Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:>98%Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.Shipping Code:RT
