Metals and biological systems
Many enzymes and systems depend on metal ions, such as zinc, iron, and copper, for proper function. These include proteases (active site function), hemoglobins (carrying oxygen), cytochromes (electron transfer), free radical control, and metal ion storage. Chelators sequester metal ions, offering a way to control or block these functions, which can be useful in infectious disease, wound healing, and heavy metal poisoning, and research in metal-dependent processes such as ferroptosis, cuproptosis, and oxidative stress.
-
Liproxstatin-1 | Ferroptosis inhibitor
From $55.00CAS:950455-15-9Catalog Number:10-4670Activity:Ferroptosis inhibitorChemical Names:N-[(3-Chlorophenyl)methyl]spiro[1,4-dihydroquinoxaline-3,4’-piperidine]-2-amineMolecular Weight:340.85Molecular Formula:C19H21ClN4Solubility:Soluble in DMSO (15 mg/ml)Physical Properties:White to off-white solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.Shipping Code:RT -
ML210 | GPX4 inhibitor / Ferroptosis inducer
From $85.00CAS:1360705-96-9Catalog Number:10-4002Activity:GPX4 inhibitor / Ferroptosis inducerChemical Name:(4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanoneMolecular Weight:475.32Molecular Formula:C22H20Cl2N4O4Solubility:Soluble in DMSO (up to 30 mg/ml)Physical Properties:White solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Nocardamine | Iron chelator/Ferroptosis inhibitor
$125.00CAS:26605-16-3Catalog Number:10-2775Activity:Iron chelator/Ferroptosis inhibitorChemical Names:1,12,23-Trihydroxy-1,6,12,17,23,28-hexazacyclotritriacontane-2,5,13,16,24,27-hexoneAlternate Name:Desferrioxamine EMolecular Weight:600.71Molecular Formula:C27H48N6O9Solubility:Soluble in DMSO (5 mg/ml)Physical Properties:Off-white solidPurity:>98% TLC
NMR (Conforms)Storage Temperature:Room temperatureStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
RSL3 | GPX4 inhibitor/Ferroptosis inducer
From $85.00CAS:1219810-16-8Catalog Number:10-3417Activity:GPX4 inhibitor/Ferroptosis inducerChemical Names:(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylateAlternate Name:1S,3R-RSL3Molecular Weight:440.88Molecular Formula:C23H21ClN2O5Solubility:Soluble in DMSO (45 mg/ml)Physical Properties:Off-white solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
SRS16-86 | Ferroptosis inhibitor
From $69.00CAS:1793052-96-6Catalog Number:10-4668Activity:Ferroptosis inhibitorChemical Names:tert-Butyl 4-(1-adamantylamino)-3-(pyrimidin-5-ylmethylideneamino)benzoateMolecular Weight:432.57Molecular Formula:C26H32N4O2Solubility:Soluble in DMSO (>25 mg/ml)Physical Properties:Yellow solidPurity:>98% TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
TPEN | Intracellular Zn2+ chelator
From $86.00CAS:16858-02-9Catalog Number:10-1228Activity:Intracellular Zn2+ chelatorChemical Name:N,N,N’,N’-Tetrakis(2-pyridylmethyl)ethylenediamineMolecular Weight:424.54Molecular Formula:C26H28N6Solubility:Soluble in DMSO (up to 10 mg/ml).Physical Properties:Off-white or tan solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
