Cytochrome P450

Cytochrome P450 enzymes (CYPs) are highly conserved enzymes that utilize iron as a cofactor to oxidize its targets, which include fatty acids, steroids, natural products, xenobiotics and drugs. CYP action on fatty acids and steroids controls their synthesis and metabolism. By acting on natural products and drugs, CYPs can decrease the activity and bioavailability of these molecules.

Inducers

  • Leelamine | Intracellular cholesterol transport inhibitor
    CAS:
    16496-99-4
    Catalog Number:
    10-2955
    Activity:
    Intracellular cholesterol transport inhibitor
    Chemical Name:
    (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
    Alternate Name:
    Lylamine HCl; (+)-Dehydroabietylamine HCl
    Molecular Weight:
    321.93
    Molecular Formula:
    C20H31N•HCl
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Water (up to 9 mg/ml).
    Physical Properties:
    Off-white or beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
  • 6-Formylindolo[3,2-b]carbazole (FICZ) | AhR endogenous agonist
    CAS:
    172922-91-7
    Catalog Number:
    10-1463
    Activity:
    AhR endogenous agonist
    Alternate Names:
    FICZ
    Molecular Weight:
    284.32
    Molecular Formula:
    C19H12N2O
    Solubility:
    Soluble in DMSO (up to 10 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    95% by TLC
    NMR (Conforms)
    Storage Temperature:
    -80°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Inducers Products

Inhibitors

  • HET0016 | 20-HETE biosynthesis inhibitor
    CAS:
    339068-25-6
    Catalog Number:
    10-5246
  • Sulconazole | Antifungal/ Prevents cancer stem cell formation
    CAS:
    61318-91-0
    Catalog Number:
    10-3955
    Activity:
    Antifungal/Prevents cancer stem cell formation
    Chemical Names:
    1-[2-[(4-Chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
    Molecular Weight:
    460.75
    Molecular Formula:
    C18H15Cl3N2S·HNO3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Omeprazole | Proton pump inhibitor / Antiviral
    CAS:
    73590-58-6
    Catalog Number:
    10-2822
    Activity:
    Proton pump inhibitor / Antiviral
    Chemical Name:
    5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
    Molecular Weight:
    345.42
    Molecular Formula:
    C17H19N3O3S
    Solubility:
    Soluble in DMSO (up to 35 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 months.
    Shipping Code:
    RT
  • Ritonavir | HIV1/2 protease inhibitor
    CAS:
    155213-67-5
    Catalog Number:
    10-4484
    Activity:
    HIV 1/2 protease inhibitor
    Chemical Name:
    1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-2-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
    Molecular Weight:
    720.95
    Molecular Formula:
    C37H48N5O5S2
    Solubility:
    Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 5 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • 1-Aminobenzotriazole | Cytochrome P450 inhibitor
    CAS:
    1614-12-6
    Catalog Number:
    10-2508
    Activity:
    Cytochrome P450 inhibitor
    Alternate Names:
    ABT; 1-Benzotriazolylamine; NSC-114498
    Molecular Weight:
    134.14
    Molecular Formula:
    C6H6N4
    Solubility:
    Soluble in DMSO (up to 30mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Inhibitors Products

Substrates

  • 3-Cyano-7-ethoxycoumarin | CYP450 fluorescent substrate
    CAS:
    11620-77-6
    Catalog Number:
    10-1440
    Activity:
    CYP450 fluorescent substrate
    Chemical Name:
    7-Ethoxy-2-oxo-2H-1-benzopyran-3-carbonitrile
    Molecular Weight:
    215.20
    Molecular Formula:
    C12H9O3
    Solubility:
    Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming)
    Physical Properties:
    Pale Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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Plymouth Meeting, PA USA
1-855-FOCUS21

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