Programmed Cell Death

Cell death can be divided in two major categories. Necrosis results from cellular injury caused by external factors such as trauma or infection. Programmed cell death is a regulated process that is mediated by various intracellular programs. Types of programmed cell death include apoptosis, anoikis, necroptosis, ferroptosis, pyroptosis, and parthanatos. These types of programmed cell death other than apoptosis have also been termed stress-induced cell death (SCID).

Anoikis

  • R162 | Glutamate dehydrogenase 1 inhibitor
    CAS:
    64302-87-0
    Catalog Number:
    10-4603
    Activity:
    Glutamate Dehydrogenase 1 inhibitor
    Chemical Name:
    1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
    Alternate Names:
    Purpurin analog
    Molecular Weight:
    264.28
    Molecular Formula:
    C17H12O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml or in Ethanol (up to 5 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Anisomycin | Anoikis sensitizer
    CAS:
    22862-76-6
    Catalog Number:
    10-2056
    Activity:
    Anoikis sensitizer
    Chemical Name:
    (2R,3S,4S)-4-Hydroxy-2-)4-methoxybenzyl)pyrrolidin-3-yl acetate
    Molecular Weight:
    265.31
    Molecular Formula:
    C14H19NO4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
View All Anoikis Products

Apoptosis

  • P053 | Protein phosphatase 5 inhibitor
    CAS:
    1022417-69-1
    Catalog Number:
    10-4060
  • IACS-010759 | Mitochondrial Complex I Inhibitor
    CAS:
    1570496-34-2
    Catalog Number:
    10-4475
  • Z-DEVD-FMK | Caspase-3 inhibitor
    CAS:
    210344-95-9
    Catalog Number:
    10-2904
    Activity:
    Caspase-3 inhibitor
    Chemical Names:
    Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
    Molecular Weight:
    668.67
    Molecular Formula:
    C30H41FN4O12
    Solubility:
    Soluble in DMSO (20 mg/ml)
    Physical Properties:
    Lyophilized solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • SU9516 | pan-specific CDK inhibitor
    CAS:
    SU9516
    Catalog Number:
    10-5705
    Activity:
    pan-specific CDK inhibitor
    Chemical Names:
    (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-2-one
    Molecular Weight:
    241.25
    Molecular Formula:
    C13H11N3O2
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • ABT-737 | Senolytic Bcl2 inhibitor
    CAS:
    852808-04-9
    Catalog Number:
    10-3661
    Activity:
    Senolytic Bcl inhibitor
    Chemical Names:
    4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide
    Molecular Weight:
    813.43
    Molecular Formula:
    C42H45ClN6O5S2
    Solubility:
    Soluble in DMSO (5 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Apoptosis Products

Ferroptosis

View All Ferroptosis Products

Methuosis

  • MOMIPP | Methuosis inducer
    CAS:
    1363421-46-8
    Catalog Number:
    10-4766
    Activity:
    Methuosis Inducer
    Chemical Names:
    trans-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one
    Molecular Weight:
    292.33
    Molecular Formula:
    C18H16N2O2
    Solubility:
    Soluble in DMSO (7 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Methuosis Products

Necroptosis

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Other Programmed Cell Death

  • Elesclomol | Copper chelator/Cuproptosis inducer
    CAS:
    488832-69-5
    Catalog Number:
    10-4238
  • Z-DEVD-FMK | Caspase-3 inhibitor
    CAS:
    210344-95-9
    Catalog Number:
    10-2904
    Activity:
    Caspase-3 inhibitor
    Chemical Names:
    Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
    Molecular Weight:
    668.67
    Molecular Formula:
    C30H41FN4O12
    Solubility:
    Soluble in DMSO (20 mg/ml)
    Physical Properties:
    Lyophilized solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • BAY-876 | GLUT1 inhibitor
    CAS:
    1799753-84-6
    Catalog Number:
    10-4708
    Activity:
    GLUT1 inhibitor
    Chemical Names:
    N4-[1-(4-Cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide
    Molecular Weight:
    496.43
    Molecular Formula:
    C24H16F4N6O2
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Quinacrine HCl | Antiprotozoan / Anticancer
    CAS:
    69-05-6
    Catalog Number:
    10-4251
    Activity:
    Antiprotozoan / Anticancer
    Chemical Name:
    6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride
    Molecular Weight:
    472.88
    Molecular Formula:
    C23H30ClN3O • 2HCl
    Solubility:
    Soluble in Water (up to at least 25 mg/ml) or in DMSO (up to at least 10 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Solutions in water should be made fresh daily.
    Shipping Code:
    RT
  • Leu-Leu-OMe HBr | Lysosomal damaging agent
    CAS:
    16689-14-8
    Catalog Number:
    10-3220
    Activity:
    Lysosomal damaging agent
    Chemical Name:
    Leucyl-leucine methyl ester hydrobromide
    Alternate Names:
    LLME
    Molecular Weight:
    339.27
    Molecular Formula:
    C13H26N2O3 HBr
    Solubility:
    Soluble in DMSO (up to 35 mg/ml) or in Water (up to 40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Other Programmed Cell Death Products

Paraptosis

  • Ophiobolin A | Autophagy inducer / Anticancer
    CAS:
    4611-05-6
    Catalog Number:
    10-3150
    Activity:
    Autophagy inducer / Anticancer
    Alternate Names:
    Cochliobolin A; Ophiobalin; NSC 114340
    Molecular Weight:
    400.55
    Molecular Formula:
    C25H36O4
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
View All Paraptosis Products

Pyroptosis

  • 1G244 | DPP8/9 inhibitor
    CAS:
    847928-32-9
    Catalog Number:
    10-4584
    Activity:
    DPP8/9 inhibitor
    Chemical Names:
    (S)-2-Amino-4-{4-[bis-(4-fluorophenyl)-methyl]piperazin-1-yl}-1-(1,3-dihydro-isoindol-2-yl)-butane-1,4-dione
    Alternate Name:
    PTX-1210
    Molecular Weight:
    504.57
    Molecular Formula:
    C29H30F2N4O2
    Solubility:
    Soluble in DMSO (>20 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • Belnacasan | ICE/caspase-1 inhibitor
    CAS:
    273404-37-8
    Catalog Number:
    10-4399
    Activity:
    ICE/caspase-1 inhibitor
    Chemical Names:
    (S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide; VX-765
    Molecular Weight:
    508.99
    Molecular Formula:
    C24H33ClN4O6
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Off-white to white solid
    Purity:
    98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Talabostat mesylate | Pyroptosis inducer / Inflammasome activator
    CAS:
    150080-09-4
    Catalog Number:
    10-4005
    Activity:
    Pyroptosis inducer / Inflammasome activator
    Chemical Name:
    ((2R)-1-((2S)-2-Amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid methanesulfonate
    Alternate Names:
    Val-boroPro; PT-100
    Molecular Weight:
    310.18
    Molecular Formula:
    C9H19BN2O3 • CH3SO3H
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    97% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Pyroptosis Products

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