March 30, 2023
New Product Focus: Chroman 1 is an important new small molecule tool for the generation and maintenance of stem cells. An extremely potent (1 pM) inhibitor […]
September 1, 2022
Chroman 1 is an important new small molecule tool for the generation and maintenance of stem cells. An extremely potent (1 pM) inhibitor of Rho kinase […]
June 22, 2022
Kumar et al. and Zijlmans et al. have published in Nature Cell Biology that Polycomb repressive complex 2 (PRC2) epigenetically reduces lineage potential of hESCs. They […]
May 12, 2022
In Nature Communications, Zhang et al. show that DJ001, a selective allosteric inhibitor of protein tyrosine phosphatase sigma (PTPσ), promotes hematopoietic stem cell (HSC) regeneration. Treatment […]
April 27, 2022
CHIR-99021 is another popular tool for stem cell maintenance which increases cell survival and proliferation. It is a GSK3β inhibitor, and Komiya et al. used CHIR-99021 […]
April 14, 2022
The compound Y-27632 inhibits ROCK family kinases and is a very popular tool for embryonic stem cell (ESC) maintenance because it enhances survival and proliferation in […]
February 7, 2022
A team at Toronto’s Hospital for Sick Children demonstrated that pharmacological ablation of senescent cells using Navitoclax (ABT-263, Focus Cat#10-3141) caused a rapid increase in neural […]
