Approved Drugs
Drugs approved by the FDA or other agencies for use in medicine are excellent tools for research because they are demonstrated to have good absorption (bioavailable), distribution and activity, and pharmacokinetics for use in vivo experiments. They are used in cells or animals for basic research, and for drug discovery (repurposing, benchmarking and other applications).
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Vismodegib | Sonic Hedgehog signaling pathway inhibitor
From $60.00CAS:879085-55-9Catalog Number:10-2182Activity:Sonic Hedgehog signaling pathway inhibitorChemical Name:2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamideAlternate Names:GDC-0449Molecular Weight:421.3Molecular Formula:C19H14Cl2N2O3SSolubility:Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 10 mg/ml with warming)Physical Properties:Off-white or beige solidPurity:99% by TLC and HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Zafirlukast | HSP70 inhibitor and leukotriene antagonist
From $28.00CAS:107753-78-6Catalog Number:10-1100Activity:Hsp70 inhibitorAlternate Names:ICI-204219Molecular Weight:575.69Molecular Formula:C31H33N3O6SSolubility:Soluble in DMSO (up to 10 mg/ml).Physical Properties:White or pink solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Zileuton | 5-LO inhibitor
From $32.00CAS:111406-87-2Catalog Number:10-1098Activity:5-LO inhibitorChemical Name:N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyureaMolecular Weight:236.29Molecular Formula:C11H12N2O2SSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:>98%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Zoledronic acid | Inhibitor of bone resorption
From $45.00CAS:118072-93-8Catalog Number:10-4512Activity:Antiproliferative and apopototic effectsAlternate Names:CGP 42446Chemical Name:[1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)Molecular Weight:272.09Molecular Formula:C5H10N2O7P2Solubility:Soluble in Water (up to 2 mg/ml).Physical Properties:White or off-white solidPurity:98% by HPLCStorage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.Shipping Code:RT
