Approved Drugs
Drugs approved by the FDA or other agencies for use in medicine are excellent tools for research because they are demonstrated to have good absorption (bioavailable), distribution and activity, and pharmacokinetics for use in vivo experiments. They are used in cells or animals for basic research, and for drug discovery (repurposing, benchmarking and other applications).
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Tofacitinib | JAK inhibitor
From $60.00CAS:477600-75-2Catalog Number:10-2177Activity:JAK inhibitorAlternate Names:Tasocitinib, CP-690550Molecular Weight:312.37Molecular Formula:C16H20N6OSolubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).Physical Properties:Off-white solidPurity:99% by HPLC and TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Trametinib | MEK inhibitor
From $40.00CAS:871700-17-3Catalog Number:10-4759Activity:MEK inhibitorChemical Name:N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamideAlternate Names:GSK1120212Molecular Weight:615.39Molecular Formula:C26H23FIN5O4Solubility:Soluble in DMSO (up to 20 mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
Tranilast | Antiallergy agent
From $40.00CAS:53902-12-8Catalog Number:10-2234Activity:NFκB inhibitorAlternate Names:RizabenChemical Name:N-(3′,4′-Dimethoxycinnamoyl)anthranilic acidMolecular Weight:327.34Molecular Formula:C18H17NO5Solubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:Pale yellow solidPurity:98% by TLC
NMR (Conforrms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Trifluorothymidine | Proapoptotic antiproliferative agent
From $45.00CAS:70-00-8Catalog Number:10-1283Activity:Thymidylate synthase inhibitor / Anti-cancer agentChemical Name:2’-Deoxy-5-trifluoromethyluridineAlternate Names:α,α,α-Trifluorothymidine; Trifluorothymine deoxyriboside; Trifluridine; TFTMolecular Weight:296.20Molecular Formula:C10H11F3N2O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml)Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT -
Valsartan | Angiotensin antagonist
From $50.00CAS:137862-53-4Catalog Number:10-2052Activity:Angiotensin antagonistAlternate Names:CGP-48933Chemical Name:(S)-3-Methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-pentanamido]butanoic acidMolecular Weight:435.52Molecular Formula:C24H29N5O3Solubility:Soluble in DMSO (up to 40 mg/ml).Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Varenicline tartrate | α4ß2 partial agonist/Smoking cessation aid
From $75.00Varenicline (375815-87-5) is a partial agonist of the α4β2 neuronal nicotinic acetylcholine receptor (EC50 = 2.3 µM) and a full agonist at α7 neuronal nicotinic receptors.1 Clinically useful […]
