Approved Drugs
Drugs approved by the FDA or other agencies for use in medicine are excellent tools for research because they are demonstrated to have good absorption (bioavailable), distribution and activity, and pharmacokinetics for use in vivo experiments. They are used in cells or animals for basic research, and for drug discovery (repurposing, benchmarking and other applications).
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Tetrabenazine | VMAT2 inhibitor
From $30.00CAS:58-46-8Catalog Number:10-2672Activity:VMAT2 inhibitorChemical Name:(3R,11bR)-rel-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-oneMolecular Weight:317.43Molecular Formula:C19H27NO3Solubility:Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 9 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.Shipping Code:RT -
Thalidomide | E3 UB ligase inhibitor
From $50.00CAS:50-35-1Catalog Number:10-1115Activity:E3 UB ligase inhibitorChemical Name:N-(2,6-Dioxo-3-piperidinyl)phthalimide, racemicMolecular Weight:258.25Molecular Formula:C13H10N2O4Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor
From $35.00CAS:145821-59-6Catalog Number:10-4384Activity:GABA transporter 1 (GAT1) inhibitorChemical Name:(3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acidAlternate Name:NO-328Molecular Weight:412.00Molecular Formula:C20H25NO2S2 • HClSolubility:Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)Physical Properties:Off-white or beige solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.Shipping Code:RT -
Tianeptine sodium salt | Neuroprotective agent
From $40.00CAS:30123-17-2Catalog Number:10-2937Activity:Neuroprotective agentChemical Name:7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidibenzo[c,f][1,2]thiazepin-11-yl)amino]heptamoic acid, sodium saltMolecular Weight:458.93Molecular Formula:C21H24ClN2O4SSolubility:Soluble in DMSO (up to 5 mg/ml) or in Water (up to 45 mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.Shipping Code:RT -
Tofacitinib | JAK inhibitor
From $60.00CAS:477600-75-2Catalog Number:10-2177Activity:JAK inhibitorAlternate Names:Tasocitinib, CP-690550Molecular Weight:312.37Molecular Formula:C16H20N6OSolubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).Physical Properties:Off-white solidPurity:99% by HPLC and TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Trametinib | MEK inhibitor
From $40.00CAS:871700-17-3Catalog Number:10-4759Activity:MEK inhibitorChemical Name:N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamideAlternate Names:GSK1120212Molecular Weight:615.39Molecular Formula:C26H23FIN5O4Solubility:Soluble in DMSO (up to 20 mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT
